Exhibit 99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS THIRD QUARTER RESULTS

Operations of 17 Former Steward Hospitals Transitioned to Five New Operators

Approximately $2.9 Billion of Year-to-Date Liquidity Transactions Completed

Birmingham, AL – November 7, 2024 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) today announced financial and operating results for the third quarter ended September 30, 2024, as well as certain events occurring subsequent to quarter end.

Third Quarter Financial Highlights

Corporate Updates During and Subsequent to the Third Quarter

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Edward K. Aldag, Jr., Chairman, President and Chief Executive Officer, said, “Across our highly diversified, global portfolio, we are excited by the positive trends we continue to see in utilization, acuity mix, and reimbursements. Further, as a result of our recent global settlement and our team’s tireless efforts, we successfully re-tenanted 17 Steward hospitals across five states to ensure continuity of patient care and recover our annual cash flows associated with these properties. With Steward’s removal from our portfolio, we look forward to demonstrating the strength and resilience of our diversified portfolio of hospital real estate and the importance of our business model to an industry in desperate need for more capital solutions.”

Included in the financial tables accompanying this press release is information about the Company’s assets and liabilities, operating results, and reconciliations of net (loss) income to NFFO, including per share amounts, all on a basis comparable to 2023 results.

PORTFOLIO UPDATE

Medical Properties Trust has total assets of approximately $15.2 billion, including $9.4 billion of general acute facilities, $2.5 billion of behavioral health facilities and $1.7 billion of post-acute facilities. As of September 30, 2024, MPT’s portfolio included 402 properties and approximately 40,000 licensed beds leased to or mortgaged by 55 hospital operating companies across the United States as well as in the United Kingdom, Switzerland, Germany, Spain, Finland, Colombia, Italy and Portugal.

MPT’s European general acute portfolio continues to benefit from the expanding role of private hospitals in addressing rapidly growing care needs, particularly in the U.K. with a strong year-over-year increase in surgical volumes, occupancy rates, and reimbursement rates. Swiss Medical Network (“SMN”) reported organic growth as well as meaningful benefit from ongoing cost optimization efforts. In September, SMN opened its Genolier Innovation Hub which is expected to serve as a venue for leading industry minds to collaborate to facilitate continuous improvement of healthcare for patients and future generations. Behavioral and post-acute operations have remained consistent, with MEDIAN reporting strong performance across all key revenue metrics and Priory recording increases in revenue due to improved reimbursement and acuity mix.

In the Company’s U.S. portfolio, general acute revenue trends continue to benefit from increasing admissions, surgeries, and higher reimbursement rates. Further, coverages in MPT’s behavioral portfolio continue to improve due to steadily rising volumes, reduced utilization of contract labor and the ramp-up of expanded facilities. MPT’s portfolio of general acute hospitals operated by Lifepoint Health continues to demonstrate accelerating profitability as the operator’s self-funded expansion of Conemaugh Memorial Medical Center in Johnstown, Pennsylvania has driven significantly higher volumes while labor costs have continued to moderate. Overall performance of the post-acute segment, which combines inpatient rehabilitation (“IRF”) and long-term acute care (“LTACH”) facilities, remained stable.

During the third quarter of 2024, Prospect did not pay cash rent related to the six California properties it leases from MPT. Prospect’s California properties continue to report improving facility level EBITDARM coverage trends. However, Prospect’s operating losses in multiple east coast markets that it is attempting to exit – including Pennsylvania and Rhode Island (a state where MPT does not have any real estate investments) – have adversely impacted overall liquidity. Prospect expects to receive $100 million of quality assurance fund (“QAF”) payments in the first quarter of 2025.

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STEWARD UPDATE

MPT received approximately $10 million in consolidated cash rent from Steward in the third quarter prior to finalization of its global settlement agreement with Steward and its creditors in September. This global settlement restored MPT’s control over its real estate, severed its relationship with Steward, and facilitated the re-tenanting of 17 properties previously leased to Steward.

MPT reached definitive agreements with Healthcare Systems of America, HonorHealth, Quorum Health, Insight Health and most recently College Health to lease and operate these 17 facilities. The five new tenants are in-place and executing on their transition strategies. Since the global settlement, the Company has provided approximately $90 million in overall working capital loans to these operators and is receiving cash interest payments. The short-term loans will provide liquidity until their facility-level receivables are sufficient to raise asset-backed loans. This represents a modest increase versus the $80 million previously disclosed due to larger than expected legal and professional fees as well as other costs related to the hospital operations transition process. MPT expects to begin to receive partial cash rental payments from the re-tenanted portfolio in the first quarter of 2025.

In October, MPT received approximately $45 million in cash related to Steward’s sale of three former MPT hospitals on Florida’s “Space Coast” to Orlando Health for total consideration of approximately $440 million. As previously disclosed, Steward retained approximately $395 million of proceeds from the sale as part of the global settlement agreement. In turn, Steward and its creditors relinquished all rights to any further allocation of value from transactions related to any other hospital remaining in the portfolio and the parties agreed to mutually dismiss claims against each other and exchange broad general releases.

OPERATING RESULTS

Net loss for the third quarter ended September 30, 2024 was ($801 million), or ($1.34) per share, compared to net income of $117 million, or $0.19 per share, in the year earlier period. Net loss for the quarter ended September 30, 2024 included approximately $130 million in real estate gains resulting from asset sale transactions, approximately $608 million of impairment charges, $131 million of net negative fair value adjustments and $137 million accelerated non-cash amortization of in-place lease intangibles (included in real estate depreciation and amortization). These primarily consisted of:

NFFO for the third quarter ended September 30, 2024 was $94 million, or $0.16 per share, compared to $226 million, or $0.38 per share in the year earlier period.

CONFERENCE CALL AND WEBCAST

The Company has scheduled a conference call and webcast for November 7, 2024 at 11:00 a.m. Eastern Time to present the Company’s financial and operating results for the quarter ended September 30, 2024. The dial-in numbers for the conference call are 877-883-0383 (U.S.) and 412-902-6506 (International) along with passcode 6768920. The conference call will also be available via webcast in the Investor Relations section of the Company’s website, www.medicalpropertiestrust.com.

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A telephone and webcast replay of the call will be available beginning shortly after the call’s completion. The telephone replay will be available through November 21, 2024, using dial-in numbers 877-344-7529 (U.S.), 855-669-9658 (Canada) and 412-317-0088 (International) along with passcode 6635503. The webcast replay will be available for one year following the call’s completion on the Investor Relations section of the Company’s website.

The Company’s supplemental information package for the current period will also be available on the Company’s website in the Investor Relations section.

The Company uses, and intends to continue to use, the Investor Relations page of its website, which can be found at www.medicalpropertiestrust.com, as a means of disclosing material nonpublic information and of complying with its disclosure obligations under Regulation FD, including, without limitation, through the posting of investor presentations that may include material nonpublic information. Accordingly, investors should monitor the Investor Relations page, in addition to following our press releases, SEC filings, public conference calls, presentations and webcasts. The information contained on, or that may be accessed through, our website is not incorporated by reference into, and is not a part of, this document.

About Medical Properties Trust, Inc.

Medical Properties Trust, Inc. is a self-advised real estate investment trust formed in 2003 to acquire and develop net-leased hospital facilities. From its inception in Birmingham, Alabama, the Company has grown to become one of the world’s largest owners of hospital real estate with 402 facilities and approximately 40,000 licensed beds in nine countries and across three continents as of September 30, 2024. MPT’s financing model facilitates acquisitions and recapitalizations and allows operators of hospitals to unlock the value of their real estate assets to fund facility improvements, technology upgrades and other investments in operations. For more information, please visit the Company’s website at www.medicalpropertiestrust.com.

Forward-Looking Statements

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use of forward-looking words such as “may”, “will”, “would”, “could”, “expect”, “intend”, “plan”, “estimate”, “target”, “anticipate”, “believe”, “objectives”, “outlook”, “guidance” or other similar words, and include statements regarding our strategies, objectives, asset sales and other liquidity transactions (including the use of proceeds thereof), expected re-tenanting of vacant facilities and any related regulatory approvals, and expected outcomes from Steward’s Chapter 11 restructuring process, including the terms of the agreement described in this press release. Forward-looking statements involve known and unknown risks and uncertainties that may cause our actual results or future events to differ materially from those expressed in or underlying such forward-looking statements, including, but not limited to: (i) the risk that the outcome and terms of the bankruptcy restructuring of Steward will not be consistent with those anticipated by the Company; (ii) the risk that the Company is unable to successfully re-tenant the Steward portfolio hospitals, on the terms described herein or at all; (iii) the risk that previously announced or contemplated property sales, loan repayments, and other capital recycling transactions do not occur as anticipated or at all; (iv) the risk that MPT is not able to attain its leverage, liquidity and cost of capital objectives within a reasonable time period or at all; (v) MPT’s ability to obtain debt financing on attractive terms or at all, as a result of changes in interest rates and other factors, which may adversely impact its ability to pay down, refinance, restructure or extend its indebtedness as it becomes due, or pursue acquisition and development opportunities; (vi) the ability of our tenants, operators and borrowers to satisfy their obligations under their respective contractual arrangements with us; (vii) the ability of our tenants and operators to

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operate profitably and generate positive cash flow, remain solvent, comply with applicable laws, rules and regulations in the operation of our properties, to deliver high-quality services, to attract and retain qualified personnel and to attract patients; (viii) the risk that we are unable to monetize our investments in certain tenants at full value within a reasonable time period or at all, (ix) our success in implementing our business strategy and our ability to identify, underwrite, finance, consummate and integrate acquisitions and investments; and (x) the risks and uncertainties of litigation or other regulatory proceedings.

The risks described above are not exhaustive and additional factors could adversely affect our business and financial performance, including the risk factors discussed under the section captioned “Risk Factors” in our most recent Annual Report on Form 10-K and our Form 10-Q, and as may be updated in our other filings with the SEC. Forward-looking statements are inherently uncertain and actual performance or outcomes may vary materially from any forward-looking statements and the assumptions on which those statements are based. Readers are cautioned to not place undue reliance on forward-looking statements as predictions of future events. We disclaim any responsibility to update such forward-looking statements, which speak only as of the date on which they were made.

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MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Consolidated Balance Sheets

(Amounts in thousands, except for per share data)

(A) Financials have been derived from the prior year audited financial statements.

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Consolidated Statements of Income

(Unaudited)

(A) Includes $2.6 million and $3.3 million of ground lease and other expenses (such as property taxes and insurance) paid directly by us and reimbursed by our tenants for the three months ended September 30, 2024 and 2023, respectively, and $9.8 million and $28.6 million for the nine months ended September 30, 2024 and 2023, respectively.

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Reconciliation of Net (Loss) Income to Funds From Operations (Unaudited)

Notes:

Investors and analysts following the real estate industry utilize funds from operations (“FFO”) as a supplemental performance measure. FFO, reflecting the assumption that real estate asset values rise or fall with market conditions, principally adjusts for the effects of GAAP depreciation and amortization of real estate assets, which assumes that the value of real estate diminishes predictably over time. We compute FFO in accordance with the definition provided by the National Association of Real Estate Investment Trusts, or Nareit, which represents net income (loss) (computed in accordance with GAAP), excluding gains (losses) on sales of real estate and impairment charges on real estate assets, plus real estate depreciation and amortization, including amortization related to in-place lease intangibles, and after adjustments for unconsolidated partnerships and joint ventures.

In addition to presenting FFO in accordance with the Nareit definition, we disclose normalized FFO, which adjusts FFO for items that relate to unanticipated or non-core events or activities or accounting changes that, if not noted, would make comparison to prior period results and market expectations less meaningful to investors and analysts. We believe that the use of FFO, combined with the required GAAP presentations, improves the understanding of our operating results among investors and the use of normalized FFO makes comparisons of our operating results with prior periods and other companies more meaningful. While FFO and normalized FFO are relevant and widely used supplemental measures of operating and financial performance of REITs, they should not be viewed as a substitute measure of our operating performance since the measures do not reflect either depreciation and amortization costs or the level of capital expenditures and leasing costs (if any not paid by our tenants) to maintain the operating performance of our properties, which can be significant economic costs that could materially impact our results of operations. FFO and normalized FFO should not be considered an alternative to net income (loss) (computed in accordance with GAAP) as indicators of our results of operations or to cash flow from operating activities (computed in accordance with GAAP) as an indicator of our liquidity.

Certain line items above (such as depreciation and amortization) include our share of such income/expense from unconsolidated joint ventures. These amounts are included with all activity of our equity interests in the “Earnings (loss) from equity interests” line on the consolidated statements of income.

(A) Includes revenue accrued during the period but not received in cash, such as deferred rent, payment-in-kind (“PIK”) interest or other accruals.

(B) Includes cash received to satisfy previously accrued non-cash revenue, such as the cash receipt of previously deferred rent or PIK interest.

Exhibit 99.2

Medical Properties Trust QUARTERLY SUPPLEMENTAL 3Q 2024

3 COMPANY OVERVIEW Company Information 3 FINANCIAL INFORMATION 6 Reconciliation of Funds from Operations 6 Debt Summary 7 Debt Maturities and Debt Metrics 8 PORTFOLIO INFORMATION Lease and Loan Maturity Schedule 9 9 Total Assets and Revenues by Asset Type, Operator, State and Country 10 Rent Coverage 13 Summary of Investments and Development Projects 15 FINANCIAL STATEMENTS Consolidated Statements of Income 16 16 Consolidated Balance Sheets 17 Investments in Unconsolidated Real Estate Joint Ventures 18 Investments in Unconsolidated Operating Entities 19 Appendix—Non-GAAP Reconciliations 20 FORWARD-LOOKING STATEMENTS This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use of forward-looking words such as “may”, “will”, “would”, “could”, “expect”, “intend”, “plan”, “estimate”, “target”, “anticipate”, “believe”, “objectives”, “outlook”, “guidance” or other similar words, and include statements regarding our strategies, objectives, asset sales and other liquidity transactions (including the use of proceeds thereof), expected re-tenanting of vacant facilities and any related regulatory approvals, and expected outcomes from Steward’s Chapter 11 restructuring process, including the terms of the agreement described in this press release. Forward-looking statements involve known and unknown risks and uncertainties that may cause our actual results or future events to differ materially from those expressed in or underlying such forward-looking statements, including, but not limited to: (i) the risk that the outcome and terms of the bankruptcy restructuring of Steward will not be consistent with those anticipated by the Company; (ii) the risk that the Company is unable to successfully re-tenant the Steward portfolio hospitals, on the terms described herein or at all; (iii) the risk that previously announced or contemplated property sales, loan repayments, and other capital recycling transactions do not occur as anticipated or at all; (iv) the risk that MPT is not able to attain its leverage, liquidity and cost of capital objectives within a reasonable time period or at all; (v) MPT’s ability to obtain debt financing on attractive terms or at all, as a result of changes in interest rates and other factors, which may adversely impact its ability to pay down, refinance, restructure or extend its indebtedness as it becomes due, or pursue acquisition and development opportunities; (vi) the ability of our tenants, operators and borrowers to satisfy their obligations under their respective contractual arrangements with us; (vii) the ability of our tenants and operators to operate profitably and generate positive cash flow, remain solvent, comply with applicable laws, rules and regulations in the operation of our properties, to deliver high-quality services, to attract and retain qualified personnel and to attract patients; (viii) the risk that we are unable to monetize our investments in certain tenants at full value within a reasonable time period or at all, (ix) our success in implementing our business strategy and our ability to identify, underwrite, finance, consummate and integrate acquisitions and investments; and (x) the risks and uncertainties of litigation or other regulatory proceedings. The risks described above are not exhaustive and additional factors could adversely affect our business and financial performance, including the risk factors discussed under the section captioned “Risk Factors” in our most recent Annual Report on Form 10-K and our Form 10-Q, and as may be updated in our other filings with the SEC. Forward-looking statements are inherently uncertain and actual performance or outcomes may vary materially from any forward-looking statements and the assumptions on which those statements are based. Readers are cautioned to not place undue reliance on forward-looking statements as predictions of future events. We disclaim any responsibility to update such forward-looking statements, which speak only as of the date on which they were made. Pictured above: Zentrum für Verhaltensmedizin—Bad Pyrmont, Germany—Operated by MEDIAN. On the cover: CUF Viseu Hospital—Viseu, Portugal—Operated by CUF. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 2

COMPANY OVERVIEW Medical Properties Trust, Inc. is a self-advised real estate investment trust formed in 2003 to acquire and develop net-leased hospital facilities. From its inception in Birmingham, Alabama, the Company has grown to become one of the world’s largest owners of hospital real estate. MPT’s financing model acilitates acquisitions and recapitalizations and allows operators of hospitals to unlock the value of their real estate assets to fund facility improvements, technology upgrades and other investments in operations. 402 55 ~40,000 31 9 properties operators beds U.S. states countries MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 3

MPT Officers Edward K. Aldag, Jr. Chairman, President and Chief Executive Officer R. Steven Hamner Executive Vice President and Chief Financial Officer J. Kevin Hanna Senior Vice President, Controller and Chief Accounting Officer Rosa H. Hooper Senior Vice President of Operations and Secretary Larry H. Portal Senior Vice President, Senior Advisor to the CEO Charles R. Lambert Senior Vice President of Finance and Treasurer R. Lucas Savage Vice President, Head of Global Acquisitions Board of Directors Corporate Headquarters Edward K. Aldag, Jr. G. Steven Dawson Medical Properties Trust, Inc. R. Steven Hamner 1000 Urban Center Drive, Suite 501 Caterina A. Mozingo Birmingham, AL 35242 Emily W. Murphy Elizabeth N. Pitman (205) 969-3755 D. Paul Sparks, Jr. (205) 969-3756 (fax) Michael G. Stewart www.medicalpropertiestrust.com C. Reynolds Thompson, III MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 4

INVESTOR RELATIONS Drew Babin Tim Berryman Head of Financial Strategy and Investor Relations Managing Director of Investor Relations (646) 884-9809 dbabin@medicalpropertiestrust.com (205) 397-8589 tberryman@medicalpropertiestrust.com Transfer Stock Exchange Agent Listing and Trading Symbol Equiniti Trust Company, LLC New York Stock Exchange 6201 15th Avenue (NYSE): MPW Brooklyn, NY 11219 https://equiniti.com/us CUF Viseu Hospital—Viseu, Portugal—Operated by CUF. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 5

FINANCIAL INFORMATION RECONCILIATION OF NET (LOSS) INCOME TO FUNDS FROM OPERATIONS (Unaudited) (Amounts in thousands, except per share data) For the Three Months Ended For the Nine Months Ended September 30, 2024 September 30, 2023 September 30, 2024 September 30, 2023 FFO INFORMATION: Net (loss) income attributable to MPT common stockholders $ (801,163) $ 116,710 $ (1,997,423) $ 107,467 Participating securities’ share in earnings (153) (311) (807) (1,295) Net (loss) income, less participating securities’ share in earnings $ (801,316) $ 116,399 $ (1,998,230) $ 106,172 Depreciation and amortization 218,646 96,280 430,128 580,484 (Gain) loss on sale of real estate (91,795) 20 (475,196) (209) Real estate impairment charges 179,952 3,750 679,276 55,854 Funds from operations $ (494,513) $ 216,449 $ (1,364,022) $ 742,301 Write-off of billed and unbilled rent and other (159) 52,742 2,846 150,576 Other impairment charges, net 427,970—1,169,943 37,434 Litigation and other 28,899 2,759 46,507 12,987 Share-based compensation adjustments —1,243—(3,120) Non-cash fair value adjustments 130,949 (46,815) 511,472 (42,562) Tax rate changes and other 8—4,596 (164,535) Debt refinancing and unutilized financing costs (benefit) 713 (862) 3,677 (46) Normalized funds from operations $ 93,867 $ 225,516 $ 375,019 $ 733,035 Certain non-cash and related recovery information: Share-based compensation $ 14,427 $ 10,210 $ 30,581 $ 32,839 Debt costs amortization $ 4,994 $ 5,016 $ 14,769 $ 15,340 Non-cash rent and interest revenue (A) $—$ (31,323) $—$ (181,680) Cash recoveries of non-cash rent and interest revenue (B) $ 552 $ 2,351 $ 6,840 $ 36,087 Straight-line rent revenue from operating and finance leases $ (41,363) $ (61,003) $ (129,395) $ (184,417) PER DILUTED SHARE DATA: Net (loss) income, less participating securities’ share in earnings $ (1.34) $ 0.19 $ (3.33) $ 0.18 Depreciation and amortization 0.37 0.16 0.72 0.97 (Gain) loss on sale of real estate (0.15)—(0.79)—Real estate impairment charges 0.30 0.01 1.13 0.09 Funds from operations $ (0.82) $ 0.36 $ (2.27) $ 1.24 Write-off of billed and unbilled rent and other —0.09—0.25 Other impairment charges, net 0.71—1.94 0.06 Litigation and other 0.05 0.01 0.08 0.02 Share-based compensation adjustments ——(0.01) Non-cash fair value adjustments 0.22 (0.08) 0.85 (0.07) Tax rate changes and other — 0.01 (0.27) Debt refinancing and unutilized financing costs (benefit) — 0.01—Normalized funds from operations $ 0.16 $ 0.38 $ 0.62 $ 1.22 Certain non-cash and related recovery information: Share-based compensation $ 0.02 $ 0.02 $ 0.05 $ 0.06 Debt costs amortization $ 0.01 $ 0.01 $ 0.02 $ 0.03 Non-cash rent and interest revenue (A) $—$ (0.05) $—$ (0.30) Cash recoveries of non-cash rent and interest revenue (B) $—$—$ 0.01 $ 0.06 Straight-line rent revenue from operating and finance leases $ (0.07) $ (0.11) $ (0.22) $ (0.31) Notes: Investors and analysts following the real estate industry utilize funds from operations (“FFO”) as a supplemental performance measure. FFO, reflecting the assumption that real estate asset values rise or fall with market conditions, principally adjusts for the effects of GAAP depreciation and amortization of real estate assets, which assumes that the value of real estate diminishes predictably over time. We compute FFO in accordance with the definition provided by the National Association of Real Estate Investment Trusts, or Nareit, which represents net income (loss) (computed in accordance with GAAP), excluding gains (losses) on sales of real estate and impairment charges on real estate assets, plus real estate depreciation and amortization, including amortization related to in-place lease intangibles, and after adjustments for unconsolidated partnerships and joint ventures. In addition to presenting FFO in accordance with the Nareit definition, we disclose normalized FFO, which adjusts FFO for items that relate to unanticipated or non-core events or activities or accounting changes that, if not noted, would make comparison to prior period results and market expectations less meaningful to investors and analysts. We believe that the use of FFO, combined with the required GAAP presentations, improves the understanding of our operating results among investors and the use of normalized FFO makes comparisons of our operating results with prior periods and other companies more meaningful. While FFO and normalized FFO are relevant and widely used supplemental measures of operating and financial performance of REITs, they should not be viewed as a substitute measure of our operating performance since the measures do not reflect either depreciation and amortization costs or the level of capital expenditures and leasing costs (if any not paid by our tenants) to maintain the operating performance of our properties, which can be significant economic costs that could materially impact our results of operations. FFO and normalized FFO should not be considered an alternative to net income (loss) (computed in accordance with GAAP) as indicators of our results of operations or to cash flow from operating activities (computed in accordance with GAAP) as an indicator of our liquidity. Certain line items above (such as depreciation and amortization) include our share of such income/expense from unconsolidated joint ventures. These amounts are included with all activity of our equity interests in the “Earnings (loss) from equity interests” line on the consolidated statements of income. Includes revenue accrued during the period but not received in cash, such as deferred rent, payment-in-kind (“PIK”) interest or other accruals. Includes cash received to satisfy previously accrued non-cash revenue, such as the cash receipt of previously deferred rent or PIK interest. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 6

FINANCIAL INFORMATION (As of September 30, 2024) ($ amounts in thousands) DEBT SUMMARY Debt Instrument Rate Type Rate Balance 2026 Credit Facility Revolver(A)(B) Variable 6.378%—8.211% $ 397,391 2027 Term Loan(B) Variable 7.945% 200,000 3.325% Notes Due 2025 (€500M)(A) Fixed 3.325% 556,750 2025 GBP Term Loan (£523M)(A) Fixed(C) 3.699% 699,512 0.993% Notes Due 2026 (€500M)(A) Fixed 0.993% 556,750 5.250% Notes Due 2026 Fixed 5.250% 500,000 2.500% Notes Due 2026 (£500M)(A) Fixed 2.500% 668,750 5.000% Notes Due 2027 Fixed 5.000% 1,400,000 3.692% Notes Due 2028 (£600M)(A) Fixed 3.692% 802,500 4.625% Notes Due 2029 Fixed 4.625% 900,000 3.375% Notes Due 2030 (£350M)(A) Fixed 3.375% 468,125 3.500% Notes Due 2031 Fixed 3.500% 1,300,000 2034 Secured GBP Term Loan (£631M)(A) Fixed 6.877% 844,470 $ 9,294,248 Debt issuance costs and discount (78,497) Weighted average rate 4.259% $ 9,215,751 Variable 6% Fixed 94% Non-USD denominated debt converted to U.S. dollars at September 30, 2024. Amended Credit Facility agreement on August 6, 2024 which, among other things, reduced total revolving commitments to $1.28 billion and increased borrowing spreads to 300 basis points effective June 30, 2024 during the Modified Covenant Period. We entered into an interest rate swap transaction, effective March 6, 2020, to fix the benchmark variable interest rate of the loan. Effective June 30, 2024, the rate increased to 3.699% during the Modified Covenant Period. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 7

FINANCIAL INFORMATION (As of September 30, 2024) ($ amounts in thousands) DEBT MATURITIES Year Senior Unsecured Term Loans/Revolver Total Debt % of Total Notes 2024 $—$—$—0.0% 2025 556,750 699,512 1,256,262 13.5% 2026 1,725,500 397,391 2,122,891 22.9% 2027 1,400,000 200,000 1,600,000 17.2% 2028 802,500—802,500 8.6% 2029 900,000—900,000 9.7% 2030 468,125—468,125 5.0% 2031 1,300,000—1,300,000 14.0% 2032 ——0.0% 2033 ——0.0% 2034 —844,470 844,470 9.1% Totals $ 7,152,875 $ 2,141,373 $ 9,294,248 100.0% DEBT BY LOCAL CURRENCY Senior Unsecured Term Loans/Revolver Total Debt % of Total Notes United States $ 4,100,000 $ 260,000 $ 4,360,000 46.9% United Kingdom 1,939,375 1,543,982 3,483,357 37.5% Europe 1,113,500 337,391 1,450,891 15.6% Totals $ 7,152,875 $ 2,141,373 $ 9,294,248 100.0% DEBT METRICS For the Three Months Ended September 30, 2024 Adjusted Net Debt to Annualized EBITDAre Ratios: Adjusted Net Debt $ 8,453,402 Adjusted Annualized EBITDAre 877,240 Adjusted Net Debt to Adjusted Annualized EBITDAre Ratio 9.6x Adjusted Net Debt $ 8,453,402 Transaction Adjusted Annualized EBITDAre 886,156 Adjusted Net Debt to Transaction Adjusted Annualized EBITDAre Ratio 9.5x Leverage Ratio: Unsecured Debt $ 8,449,778 Secured Debt 844,470 Total Debt $ 9,294,248 Total Gross Assets(A) 16,659,858 Financial Leverage 55.8% Interest Coverage Ratio: Interest Expense $ 106,243 Capitalized Interest 2,006 Debt Costs Amortization (4,777) Total Interest $ 103,472 Adjusted EBITDAre $ 219,310 Adjusted Interest Coverage Ratio 2.1x Total Gross Assets equals total assets plus accumulated depreciation and amortization. See appendix for reconciliation of Non-GAAP financial measures. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 8

PORTFOLIO INFORMATION LEASE AND LOAN MATURITY SCHEDULE (A) ($ amounts in thousands) Years of Maturities(B) 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 Thereafter Total Properties(C) 3 3 2 3 8 6 9 4 22 5 311 376 Base Rent/Interest(D) 3,452 4,962 1,152 5,088 20,880 16,269 6,205 4,919 53,128 6,201 972,592 1,094,848 Percentage of Total Base Rent/Interest 0.3% 0.5% 0.1% 0.4% 1.9% 1.5% 0.6% 0.4% 4.9% 0.6% 88.8% 100.0% Percentage of total base rent/interest 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% .3% 0.5% 0.1% 0.4% 1.9% 1.5% 0.6% 0.4% 0.6% 88.8% (A) Schedule includes leases and mortgage loans and related terms as of September 30, 2024. (B) Lease/Loan expiration is based on the fixed term of the lease/loan and does not factor in potential renewal or other options provided for in our agreements. (C) Reflects all properties, including those that are part of joint ventures, except vacant properties (less than 1% of total assets), facilities that are under development, and transitioning properties. (D) Represents base rent/interest income contractually owed per the lease/loan agreements on an annualized basis as of period end (including foreign currency exchange rates) but does not include tenant recoveries, additional rents and other lease-related adjustments to revenue (i.e., straight-line rents and deferred revenues), or any reserves or write-offs. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 9

PORTFOLIO INFORMATION TOTAL ASSETS AND REVENUES BY ASSET TYPE (September 30, 2024) ($ amounts in thousands) Asset Types Properties Total Percentage of Q3 2024 Percentage of Assets(A) Total Assets Revenues Q3 2024 Revenues General Acute Care Hospitals 177 $ 9,308,236 61.1% $ 139,075 61.6% Behavioral Health Facilities 69 2,487,861 16.3% 52,799 23.4% Post Acute Care Facilities 133 1,676,426 11.0% 30,278 13.4% Freestanding ER/Urgent Care Facilities 23 126,210 0.8% 3,675 1.6% Other—1,637,423 (B) 10.8% — Total 402 $ 15,236,156 100.0% $ 225,827 100.0% TOTAL ASSETS BY ASSET TYPE TOTAL REVENUES BY ASSET TYPE 11% 2% 1% General Acute Care Hospitals 13% 11% Behavioral Health Facilities 61% Post Acute Care Facilities 16% 23% 62% Freestanding ER/Urgent Care Facilities DOMESTIC ASSETS BY ASSET TYPE Other DOMESTIC REVENUES BY ASSET TYPE 11% 3% 2% General Acute Care Hospitals 19% 13% Behavioral Health Facilities 59% 63% Post Acute Care Facilities 11% Freestanding ER/Urgent Care Facilities 19% Other Note: Investments in operating entities are allocated pro rata based on the gross book value of the real estate. Such pro rata allocations are subject to change from period to period. Reflects total assets on our consolidated balance sheets. Includes our PHP Holdings investment of approximately $202 million. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 10

PORTFOLIO INFORMATION TOTAL ASSETS - LARGEST INDIVIDUAL FACILITY (September 30, 2024) COMPREHENSIVE PROPERTY-LEVEL UNDERWRITING FRAMEWORK Operators Circle Health Priory Group Healthcare Systems of America Prospect Medical Holdings Lifepoint Behavioral Health 50 operators Largest Individual Facility as a Percentage of Total Assets(A) 1.4% 0.9% 1.8% 1.3% 0.5% 1.6% MPT invests in real estate, not the consolidated financial performance of its tenants. Each facility is underwritten for characteristics that make the infrastructure attractive to any experienced, competent operator—not just the current tenant. If we have underwritten these correctly, then coupled with our absolute net master lease structure, our real estate will be attractive to a replacement operator, should we find it necesssary to transition. Such underwriting characteristics include: Physical Quality [GRAPHIC APPEARS HERE] Competition Largest Individual Facility Investment is Less Than 2% of MPT Investment Portfolio Demographics Financial and Market TOTAL ASSETS AND REVENUES BY OPERATOR (September 30, 2024) ($ amounts in thousands) Operators Properties Total Percentage of Q3 2024 Percentage of Assets(A) Total Assets Revenues Q3 2024 Revenues Circle Health 36 $ 2,179,805 14.3% $ 52,427 23.2% Priory Group 37 1,325,408 8.7% 25,934 11.5% Healthcare Systems of America 8 1,176,533 7.7%—0.0% Prospect Medical Holdings 13 1,042,343 6.8%—0.0% Lifepoint Behavioral Health 19 815,439 5.4% 20,117 8.9% Swiss Medical Network 19 764,822 5.0% 240 0.1% MEDIAN 81 658,645 4.3% 8,282 3.7% Ernest Health 29 617,413 4.1% 18,680 8.3% Lifepoint Health 8 482,710 3.2% 15,211 6.7% Ramsay Health Care 8 415,826 2.7% 6,691 3.0% 45 operators 144 4,119,789 27.0% 78,245 34.6% Other—1,637,423 10.8% — Total 402 $ 15,236,156 100.0% $ 225,827 100.0% Note: Investments in operating entities are allocated pro rata based on the gross book value of the real estate. Such pro rata allocations are subject to change from period to period. (A) Reflects total assets on our consolidated balance sheets. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 11

PORTFOLIO INFORMATION TOTAL ASSETS AND REVENUES BY U.S. STATE AND COUNTRY (September 30, 2024) ($ amounts in thousands) U.S. States and Other Countries Properties Total Percentage of Q3 2024 Percentage of Assets(A) Total Assets Revenues Q3 2024 Revenues Texas 50 $ 1,367,932 9.0% $ 22,741 10.1% California 18 1,051,443 6.9% 12,449 5.5% Florida 9 890,879 5.8% 4,669 2.1% Pennsylvania 9 455,757 3.0% 8,108 3.6% Arizona 10 380,756 2.5% 7,999 3.5% 26 Other States 83 2,890,763 19.0% 59,674 26.4% Other —858,750 5.7%——United States 179 $ 7,896,280 51.9% $ 115,640 51.2% United Kingdom 92 $ 4,283,890 28.1% $ 91,776 40.6% Switzerland 19 764,821 5.0% 240 0.1% Germany 85 732,489 4.8% 10,365 4.6% Spain 9 265,574 1.7% 3,083 1.4% Other Countries 18 514,429 3.4% 4,723 2.1% Other —778,673 5.1%——International 223 $ 7,339,876 48.1% $ 110,187 48.8% Total 402 $ 15,236,156 100.0% $ 225,827 100.0% Note: Investments in operating entities are allocated pro rata based on the gross book value of the real estate. Such pro rata allocations are subject to change from period to period. (A) Reflects total assets on our consolidated balance sheets. TOTAL ASSETS BY COUNTRY TOTAL REVENUES BY COUNTRY 3% 5% 1% 2% 2% United States 5% 5% United Kingdom 5% 52% 51% Switzerland 41% Germany 28% Spain Other Countries ASSETS BY U.S. STATE Other REVENUES BY U.S. STATE 6% 9% Texas California 10% 7% Florida 19% Pennsylvania 26% 6% Arizona 2% 6% 26 Other States 4% 2% 3% Other 3% MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 12

PORTFOLIO INFORMATION TOTAL PORTFOLIO TTM EBITDARM(A)(B) RENT COVERAGE YoY and SEQUENTIAL QUARTER COMPARISONS BY PROPERTY TYPE EBITDARM Rent Coverage 3.00x 2.50x 2.7x 2.6x 2.3x 2.3x 2.00x 1.50x 1.00x 0.50x 0.00x 1.9x 1.7x 1.7x 1.6x 2.0x 2.2x 2.1x 2.1x General Acute Care Hospitals Post Acute Care Facilities (C) Behavioral Health Total Portfolio Facilities Q2 2023 TTM Q1 2024 TTM Q2 2024 TTM % of Total Assets(D) 61.1% 11.0% 16.3% 88.4% Notes: All data presented is on a trailing twelve month (“TTM”) basis. For properties acquired in the preceding twelve months, data is for the period between MPT acquisition and June 30, 2024. EBITDARM is facility-level earnings before interest, taxes, depreciation, amortization, rent and management fees. EBITDARM includes normal GAAP expensed maintenance and repair costs. EBITDARM does not give effect for capitalized expenditures that extend the life or improve the facility and equipment to increase revenues at the facility. The majority of these types of capital expenditures are financed and do not have an immediate cash impact. MPT’s rent has priority and is not subordinate to capitalized expenses. In addition, EBITDARM does not represent property net income or cash flows from operations and should not be considered an alternative to those indicators. EBITDARM figures utilized in calculating coverages presented are based on financial information provided by MPT’s tenants. MPT has not independently verified this information, but has no reason to believe this information is inaccurate in any material respect. TTM Coverages are calculated based on actual, unadjusted EBITDARM results as presented in tenant financial reporting and cash rent paid to MPT, except as noted below.—All CARES Act Grants received by tenants have been removed from the tenant’s reported financial results in the above time periods.—EBITDARM figures for California hospitals include amounts expected to be received under the Hospital Quality Assurance Fee (“HQAF”) Program 8. The HQAF amounts are based on the current payment model from the California Hospital Association which was approved by CMS on December 19, 2023. General Acute Care coverages and Total Portfolio coverages do not include Prospect Medical Holdings Connecticut facilities due to pending sale, $150M mortgage investment in Prospect Medical Holdings Pennsylvania facilities, and former Steward Health Care facilities due to re-tenanting. Post Acute Care Facilities property type includes both Inpatient Rehabilitation Hospitals and Long Term Acute Care Hospitals. Reflects percentage of total assets on September 30, 2024 balance sheet. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 13

PORTFOLIO INFORMATION TOTAL PORTFOLIO TTM EBITDARM RENT COVERAGE EXCLUSIVE OF ALL CARES ACT GRANTS EBITDARM RENT COVERAGE: OPERATORS WITH PROPERTY-LEVEL REPORTING Tenant Net Investment Primary Property Type TTM EBITDARM Rent Coverage (in thousands)(A) Priory Group $ 1,283,738 Behavioral 2.3x MEDIAN 658,645 Post Acute 1.7x Ernest Health 617,413 Post Acute 2.0x Prospect Medical Holdings(B) 509,684 General Acute 1.4x Aspris Children’s Services 252,677 Behavioral 2.2x Surgery Partners 210,789 Post Acute 7.6x Pipeline Health System 209,760 General Acute 2.0x Vibra Healthcare 194,799 General Acute 1.3x Prime Healthcare 162,108 General Acute 1.1x IMED Hospitales 130,791 General Acute 2.1x Cordiant Healthcare Services 115,761 General Acute 0.9x Ardent Health Services 83,427 General Acute 7.2x Other Reporting Tenants 453,095 Various 3.7x Total $ 4,882,687 2.4x Tenant Net Investment Primary Property Type TTM EBITDARM Rent Coverage (in thousands)(A) International Operator 1 $ 2,131,706 General Acute 2.5x Domestic Operator 1 482,710 General Acute 1.5x Domestic Operator 2 369,911 General Acute / Post Acute 1.5x Domestic Operator 3 815,439 Behavioral 1.6x Total $ 3,799,766 2.0x PROPERTY-LEVEL REPORTING NOT REQUIRED AND/OR NOT AVAILABLE Tenant Net Investment Primary Property Type Comments (in thousands)(A) Healthcare Systems of America $ 1,131,611 General Acute U.S. hospital operator with 8 community hospitals across 3 states Swiss Medical Network 515,879 General Acute Second largest group of private hospitals in Switzerland Ramsay Health Care UK 415,826 General Acute One of largest health care operators in the world; Parent guaranty; Investment grade-rated Pihlajalinna 216,049 General Acute One of Finland’s leading providers of social and health services Quorum Health 143,457 General Acute U.S. hospital operator with 12 community hospitals across 9 states Honor Health 137,748 General Acute One of Arizona’s largest nonprofit healthcare systems; Investment grade-rated Saint Luke’s—Kansas City 124,048 General Acute Investment grade-rated CommonSpirit Health 119,708 General Acute One of the largest nonprofit health care operators in the U.S.; Investment grade-rated NHS 90,641 General Acute Single-payor government entity in UK Insight Health 70,657 General Acute / Post Acute U.S. hospital operator with 9 medical centers across 4 states CUF 29,494 General Acute One of the largest private hospital systems in Portugal with 30 facilities and 75+ year operating history NeuroPsychiatric Hospitals 26,404 Behavioral Parent guaranty Community Health Systems 25,441 General Acute U.S. hospital operator with substantial operating history Total $ 3,046,963 Above data represents approximately 88% of MPT Total Real Estate Investment Notes: All data presented is on a trailing twelve month (“TTM”) basis. For properties acquired in the preceding twelve months, data is for the period between MPT acquisition and June 30, 2024. Investment figures exclude equity investments, non-real estate loans, freestanding ER/urgent care facilities, and facilities under development. Prospect Medical Holdings coverage includes California facilities only. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 14

PORTFOLIO INFORMATION SUMMARY OF INVESTMENTS (For the nine months ended September 30, 2024) (Amounts in thousands) Operator Location Investment(A) Commencement Date Capital Additions, Development and Various $ 179,102 Various Other Funding for Existing Tenants(B) $ 179,102 SUMMARY OF CURRENT DEVELOPMENT PROJECTS AS OF SEPTEMBER 30, 2024 (Amounts in thousands) Operator Location Commitment Costs Incurred as of Estimated Construction September 30, 2024 Completion Date IMED Hospitales Spain $ 38,974 $ 31,445 Q3 2025 IMED Hospitales Spain 53,427 21,594 Q3 2026 $ 92,401 $ 53,039 Excludes transaction costs, such as real estate transfer and other taxes. Amount assumes exchange rate as of the investment date. Reflects normal capital additions that extend the life or improve existing facilities on which we would expect to receive a return equal to the lease rate for the respective facility. This includes over 10 facilities and seven different operators. Note: The Texarkana, Texas development and Norwood redevelopment are omitted from this schedule. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 15

FINANCIAL STATEMENTS CONSOLIDATED STATEMENTS OF INCOME (Unaudited) (Amounts in thousands, except per share data) For the Three Months Ended For the Nine Months Ended September 30, 2024 September 30, 2023 September 30, 2024 September 30, 2023 REVENUES Rent billed $ 169,721 $ 229,306 $ 552,784 $ 724,954 Straight-line rent 36,602 21,511 119,719 38,875 Income from financing leases 9,798 26,066 53,832 107,729 Interest and other income 9,706 29,693 37,368 122,624 Total revenues 225,827 306,576 763,703 994,182 EXPENSES Interest 106,243 106,709 316,358 308,833 Real estate depreciation and amortization 204,875 77,802 382,701 526,065 Property-related(A) 4,994 6,483 17,475 38,269 General and administrative 36,625 38,110 105,300 115,438 Total expenses 352,737 229,104 821,834 988,605 OTHER (EXPENSE) INCOME Gain (loss) on sale of real estate 91,795 (20) 475,196 209 Real estate and other impairment charges, net (607,922) (3,750) (1,438,429) (93,288) Earnings (loss) from equity interests 21,643 11,264 (369,565) 34,840 Debt refinancing and unutilized financing (costs) benefit (713) 862 (3,677) 46 Other (including fair value adjustments on securities) (169,790) 41,125 (566,821) 25,447 Total other (expense) income (664,987) 49,481 (1,903,296) (32,746) (Loss) income before income tax (791,897) 126,953 (1,961,427) (27,169) Income tax (expense) benefit (9,032) (10,058) (34,538) 134,661 Net (loss) income (800,929) 116,895 (1,995,965) 107,492 Net income attributable to non-controlling interests (234) (185) (1,458) (25) Net (loss) income attributable to MPT common stockholders $ (801,163) $ 116,710 $ (1,997,423) $ 107,467 EARNINGS PER COMMON SHARE—BASIC AND DILUTED Net (loss) income attributable to MPT common stockholders $ (1.34) $ 0.19 $ (3.33) $ 0.18 WEIGHTED AVERAGE SHARES OUTSTANDING—BASIC 600,229 598,444 600,197 598,363 WEIGHTED AVERAGE SHARES OUTSTANDING—DILUTED 600,229 598,553 600,197 598,406 $— $— DIVIDENDS DECLARED PER COMMON SHARE $ 0.08 $ 0.15 $ 0.38 $ 0.73 Includes $2.6 million and $3.3 million of ground lease and other expenses (such as property taxes and insurance) paid directly by us and reimbursed by our tenants for the three months ended September 30, 2024 and 2023, respectively, and $9.8 million and $28.6 million for the nine months ended September 30, 2024 and 2023, respectively. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 16

FINANCIAL STATEMENTS CONSOLIDATED BALANCE SHEETS (Amounts in thousands, except per share data) September 30, 2024 December 31, 2023 (Unaudited) (A) ASSETS Real estate assets Land, buildings and improvements, intangible lease assets, and other $ 11,653,954 $ 13,237,187 Investment in financing leases 1,184,992 1,231,630 Real estate held for sale 85,000—Mortgage loans 298,221 309,315 Gross investment in real estate assets 13,222,167 14,778,132 Accumulated depreciation and amortization (1,423,702) (1,407,971) Net investment in real estate assets 11,798,465 13,370,161 Cash and cash equivalents 275,616 250,016 Interest and rent receivables 35,142 45,059 Straight-line rent receivables 685,742 635,987 Investments in unconsolidated real estate joint ventures 1,242,772 1,474,455 Investments in unconsolidated operating entities 508,227 1,778,640 Other loans 155,889 292,615 Other assets 534,303 457,911 Total Assets $ 15,236,156 $ 18,304,844 LIABILITIES AND EQUITY Liabilities Debt, net $ 9,215,751 $ 10,064,236 Accounts payable and accrued expenses 418,339 412,178 Deferred revenue 24,332 37,962 Obligations to tenants and other lease liabilities 136,635 156,603 Total Liabilities 9,795,057 10,670,979 Equity Preferred stock, $0.001 par value. Authorized 10,000 shares; no shares outstanding — Common stock, $0.001 par value. Authorized 750,000 shares; issued and outstanding—600,229 shares at September 30, 2024 and 598,991 shares at December 31, 2023 600 599 Additional paid-in capital 8,578,355 8,560,309 Retained deficit (3,197,505) (971,809) Accumulated other comprehensive income 57,114 42,501 Total Medical Properties Trust, Inc. Stockholders’ Equity 5,438,564 7,631,600 Non-controlling interests 2,535 2,265 Total Equity 5,441,099 7,633,865 Total Liabilities and Equity $ 15,236,156 $ 18,304,844 (A) Financials have been derived from the prior year audited financial statements. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 17

FINANCIAL STATEMENTS INVESTMENTS IN UNCONSOLIDATED REAL ESTATE JOINT VENTURES (As of and for the three months ended September 30, 2024) (Unaudited) ($ amounts in thousands) MEDIAN(B) Swiss Medical CommonSpirit(D) Policlinico di Monza(E) HM Total MPT Pro Rata Share (C) Hospitales (F) Network Gross real estate $ 1,978,762 $ 1,667,983 $ 1,264,657 $ 186,642 $ 376,996 $ 5,475,040 $ 2,736,103 Cash 41,246 2,927 50 9,733 2,557 56,513 28,701 Accumulated depreciation and amortization (280,449) (182,600) - (36,798) (38,727) (538,574) (303,870) Other assets 67,324 46,267 4,073 3,896 9,447 131,007 73,266 Total Assets $ 1,806,883 $ 1,534,577 $ 1,268,780 $ 163,473 $ 350,273 $ 5,123,986 $ 2,534,200 $ 1,115,866 Debt (third party) $ 727,963 $ 706,504 $ 770,000 $ - $ 144,071 $ 2,348,538 Other liabilities 134,563 (A) 91,104 19,948 (96) 87,930 333,449 175,562 Equity and shareholder loans 944,357 736,969 478,832 163,569 118,272 2,441,999 1,242,772 Total Liabilities and Equity $ 1,806,883 $ 1,534,577 $ 1,268,780 $ 163,473 $ 350,273 $ 5,123,986 $ 2,534,200 MPT share of real estate joint venture 50% 70% 25% 50% 45% Total $ 472,179 $ 515,878 $ 119,708 $ 81,785 $ 53,222 $ 1,242,772 MEDIAN(B) Swiss Medical CommonSpirit(D) Policlinico di Monza(E) HM Total MPT Pro Rata Share (C) Hospitales (F) Network Total revenues $ 33,910 $ 18,142 $ 21,190 $ 3,653 $ 3,911 $ 80,806 $ 38,549 Other expenses (income): Property-related $ 676 $ 1,701 $ - $ 946 $ 27 $ 3,350 $ 2,014 Interest 13,502 4,603 10,792 - 545 29,442 12,922 Real estate depreciation and amortization 11,583 9,114 - 1,061 2,091 23,849 13,643 General and administrative 750 304 - (55) 16 1,015 567 Fair value adjustments - - (53,837) - - (53,837) (13,486) Non-controlling interest expense - - 109 - - 109 27 Income taxes 1,586 377 - - 314 2,277 1,198 Total other expenses (income) $ 28,097 $ 16,099 $ (42,936) $ 1,952 $ 2,993 $ 6,205 $ 16,885 Net Income $ 5,813 $ 2,043 $ 64,126 $ 1,701 $ 918 $ 74,601 $ 21,664 MPT share of real estate joint venture 50% 70% 25% 50% 45% Earnings from equity interests $ 2,907 $ 1,429 $ 16,064 $ 851 $ 413 $ 21,664 (G) Includes a €309 million loan from both shareholders. MPT managed joint venture of 71-owned German facilities that are fully leased. Represents ownership in Infracore, which owns and leases 17 Switzerland facilities. We also have two Infracore facilities currently under development. On April 12, 2024, we closed a joint venture on five properties in Utah operated by CommonSpirit for which we hold a 25% interest accounted for under the equity method. We are recording our share of income on a quarterly lag basis. The joint venture elected to apply specialized accounting and reporting for investment companies under Topic 946, which measures the underlying investments of fair value. For this quarter, our share of the joint venture’s favorable fair value adjustment was $13.5 million, primarily related to the underlying real estate. Represents ownership in eight Italian facilities that are fully leased. Represents ownership in two Spanish facilities that are fully leased. Excludes amortization of equity investment costs.

FINANCIAL STATEMENTS INVESTMENTS IN UNCONSOLIDATED OPERATING ENTITIES (Amounts in thousands) OPERATING ENTITY INVESTMENT FRAMEWORK MPT’s hospital expertise and comprehensive underwriting process allows for opportunistic investments in hospital operations. Passive investments typically needed in order to acquire the larger real estate transactions. Cash payments go to previous owner and not to the tenant, with limited exceptions. Operators are vetted as part of our overall underwriting process. Potential for outsized returns and organic growth. Certain of these investments entitle us to customary minority rights and protections. No additional operating loss exposure beyond our investment. Proven track record of successful investments, including Ernest Health, Capella Healthcare and Springstone. Investment Operator as of Ownership September 30, Interest 2024 PHP Holdings $ 201,526 49.0% Structure Includes a 49% equity ownership interest in, along with a loan convertible into PHP Holdings, the managed care business of Prospect. Both instruments are accounted for under the fair value option method. Swiss Medical Network Aevis Priory Group Aspris Caremax International Joint Venture 185,185 8.9% 63,758 4.6% 41,670 9.2% 15,958 9.2% 9.9%— (A) 49.0% Includes our passive equity ownership interest, along with a CHF 37 million loan as part of a syndicated loan facility. Includes our passive equity ownership interest in Aevis, a public healthcare investment company. Our original investment of CHF 47 million is marked-to-market quarterly. In order to close the 2021 acquisition of 35 facilities, we made a passive equity investment and a loan to Priory (a subsidiary of MEDIAN) proceeds of which were paid to the former owner. The loan was sold in the first quarter of 2024. Includes our passive equity ownership interest in Aspris, a spin-off of Priory’s education and children’s services line of business. Includes our passive equity ownership interest in Caremax, a public care delivery system. Our original investment is marked-to-market quarterly. Includes our 49% equity ownership interest and a loan made for the purpose of investing in select international hospital operations. The loan carries a 7.5% interest rate and is secured by the remaining equity of the international joint venture and guaranteed by the other equity owner. Total $ 508,227 INVESTMENTS IN UNCONSOLIDATED OPERATING ENTITIES AS A PERCENTAGE OF TOTAL ASSETS 7% 3% 93% 97% (A) As of September 30, 2024, this investment is fully reserved. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 19

APPENDIX—NON-GAAP RECONCILIATIONS ADJUSTED NET DEBT/ANNUALIZED EBITDAre (Unaudited) (Amounts in thousands) For the Three Months Ended September 30, 2024 ADJUSTED EBITDAre RECONCILIATION Net loss $ (800,929) Add back: Interest 106,243 Income tax 9,032 Depreciation and amortization 206,474 Gain on sale of real estate (91,795) Real estate impairment charges 179,952 Adjustment to reflect MPT’s share of unlevered EBITDAre from unconsolidated real estate joint ventures(A) 7,534 3Q 2024 EBITDAre $ (383,489) Share-based compensation 14,427 Write-off of billed and unbilled rent and other (159) Other impairment charges, net 427,970 Litigation and other 28,899 Debt refinancing and unutilized financing costs 713 Non-cash fair value adjustments 130,949 Annualized 3Q 2024 Adjusted EBITDAre $ 219,310 $ 877,240 Adjustments for mid-quarter investment activity(B) 2,229 3Q 2024 Transaction Adjusted EBITDAre $ 221,539 $ 886,156 ADJUSTED NET DEBT RECONCILIATION Total debt at September 30, 2024 $ 9,215,751 Less: Cash at September 30, 2024 (275,616) Less: Cash funded for building improvements in progress and construction in progress at September 30, 2024(C) (486,733) Adjusted Net Debt $ 8,453,402 Investors and analysts following the real estate industry utilize net debt (debt less cash) to EBITDAre as a measurement of leverage that shows how many years it would take for us to pay back our debt, assuming net debt and EBITDAre are held constant. In our calculation, we start with EBITDAre , as defined by Nareit, which is net income before interest expense, income tax expense, depreciation and amortization, losses/gains on disposition of depreciated property, impairment losses, and adjustments to reflect our share of EBITDAre from unconsolidated real estate joint ventures. We then adjust EBITDAre for non-cash share-based compensation, non-cash fair value adjustments and other items that would make comparison of our operating results with prior periods and other companies more meaningful, to derive Adjusted EBITDAre . We adjust net debt for cash funded for building improvements in progress and construction in progress for which we are not yet receiving rent to derive Adjusted Net Debt. We adjust Adjusted EBITDAre for the effects from investments and capital transactions that were completed during the period, assuming such transactions were consummated/fully funded as of the beginning of the period to derive Transaction Adjusted EBITDAre . Although non-GAAP measures, we believe Adjusted Net Debt, Adjusted EBITDAre , and Transaction Adjusted EBITDAre are useful to investors and analysts as they allow for a more current view of our credit quality and allow for the comparison of our credit strength between periods and to other real estate companies without the effect of items that by their nature are not comparable from period to period. Includes only the unlevered portion of our share of EBITDAre from unconsolidated real estate joint ventures, as we have excluded any net debt from our unconsolidated real estate joint ventures in the Adjusted Net Debt line. We believe this adjustment is needed to appropriately reflect the relationship between EBITDAre and net debt. Reflects a full quarter impact from our mid-quarter investments, disposals, and loan payoffs. Excluded development and capital improvement projects that are in process and not yet generating a cash return. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q3 2024 20

1000 Urban Center Drive, Suite 501 Birmingham, AL 35242 969-3755 NYSE: MPW www.medicalpropertiestrust.com Contact: Drew Babin, Head of Financial Strategy and Investor Relations 1000 Urban Center Drive, Suite 501 Birmingham, AL 35242 (205) 969-3755 NYSE: MPW www.medicalpropertiestrust.com Contact: Drew Babin, Head of Financial Strategy and Investor Relations (646) 884-9809 or dbabin@medicalpropertiestrust.com or Tim Berryman, Managing Director of Investor Relations (205) 397-8589 or tberryman@medicalpropertiestrust.com