Exhibit 99.1

MEDICAL PROPERTIES TRUST, INC. REPORTS FIRST QUARTER RESULTS

Per Share Net Income of $0.05 and Normalized FFO of $0.37 in First Quarter

Recent Transactions Validate Underwritten Values;

Provides Additional Capital Flexibility

Declared Second Quarter Regular Dividend of $0.29 Per Share

Birmingham, AL – April 27, 2023 – Medical Properties Trust, Inc. (the “Company” or “MPT”) (NYSE: MPW) today announced financial and operating results for the first quarter ended March 31, 2023, as well as certain events occurring subsequent to quarter end.

Edward K. Aldag, Jr., Chairman, President, and Chief Executive Officer, said, “We are pleased to report a first quarter that saw our core portfolio, as it has for nearly two decades, realize attractive and predictable growth driven by strong original underwriting and inflation-based cash rent escalators. This performance establishes a baseline level of profitability that supports our dividend payments and sets the table for continued growth.”

Aldag continued, “The terms of recently announced transactions including Springstone, the acquisition by CommonSpirit of Steward’s Utah operations, Healthscope and Prime, have valued our hospital investments near and in excess of our original purchase prices. This confirmation of our underwritten asset values by sophisticated market participants, as well as our existing liquidity and prudently planned debt structure, position us to have no debt maturities until 2025.”

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Included in the financial tables accompanying this press release is information about the Company’s assets and liabilities, net income, and reconciliations of net income to NFFO and AFFO, including per share amounts, all on a basis comparable to 2022 results.

PORTFOLIO UPDATE

The Company did not acquire any new hospital real estate during the first quarter and expects aggregate acquisitions during the entire first half of 2023 of approximately $150 million. These are expected to be comprised of five behavioral hospitals acquired from and leased to Priory in England for approximately £44 million and three post-acute facilities in Germany acquired from and leased to MEDIAN for roughly €70 million.

As part of an expected series of Prospect Medical Holdings’ (“Prospect”) future strategic transactions, during the first quarter MPT provided $50 million in a loan instrument that is convertible into equity of Prospect’s managed care entity in anticipation of a larger Prospect financing transaction. Subsequent to quarter-end, Prospect received a binding commitment from a third-party lender that will provide significant liquidity for Prospect’s hospital and managed care businesses and will facilitate MPT’s conversion of certain existing and future real estate obligations of Prospect into additional managed care equity.

The Company has total assets of approximately $19.7 billion, including $13.7 billion of general acute care hospitals, $2.5 billion of behavioral health facilities and $1.7 billion of post-acute facilities. MPT’s portfolio includes 444 properties and approximately 45,000 licensed beds across the United States as well as in the United Kingdom, Switzerland, Germany, Australia, Spain, Finland, Colombia, Italy and Portugal. The properties are leased to or mortgaged by 54 hospital operating companies.

OPERATING RESULTS AND OUTLOOK

Net income for the first quarter ended March 31, 2023 was $33 million ($0.05 per diluted share) compared to $632 million ($1.05 per diluted share) in the year earlier period. Included in 2023 first quarter net income is approximately $90 million of impairment and other non-cash charges related to the expected sale of hospitals and no rent or interest revenue recognized from Prospect leases or loan investments, as compared to 2022 first quarter net income which included an approximate $452 million gain on sale, inclusive of a write-off of roughly $125 million of straight-line rent, related to the partnership transaction with Macquarie Asset Management.

NFFO for the first quarter ended March 31, 2023 was $222 million ($0.37 per diluted share) compared to $282 million ($0.47 per diluted share) in the year earlier period.

The Company is adjusting its 2023 calendar estimate of per share net income to $0.06 to $0.17 to account for first quarter results and announced transaction activity and is adjusting its estimate of per share NFFO to $1.50 to $1.61 to account for the impact of announced deleveraging asset sales (and expected $1.4 billion debt reduction). At their high-end, the ranges reflect management’s expectation that certain amounts related to Prospect are recognized as revenue during 2023, while their low-end accounts for the possibility that the entirety of this revenue is recognized subsequent to 2023. The estimates are based on an existing portfolio which includes the impact of binding disposition and leasing transactions and changes to lease terms but excludes expected future contributions from development and other capital projects.

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These estimates do not include the effects, among others, of unexpected real estate operating costs, changes in accounting pronouncements, litigation costs, debt refinancing costs, acquisition costs, currency exchange rate movements, changes in income tax rates, interest rate hedging activities, write-offs of straight-line rent and in place lease intangibles, other impairments or other non-recurring/unplanned transactions. Moreover, these estimates do not provide for the impact on MPT or its tenants and borrowers from the global COVID-19 pandemic. These estimates may change if the Company acquires or sells assets in amounts that are different from estimates, market interest rates change, debt is refinanced or repurchased, new shares are issued or repurchased, additional debt is incurred, other operating expenses vary, income from equity investments vary from expectations, or existing leases or loans do not perform in accordance with their terms.

LITIGATION UPDATE

On March 30, MPT sued short seller Viceroy Research LLC and its principals, including Fraser Perring, in federal court for defamation and related wrongs arising from their campaign of malicious falsehoods calculated to reap profits for themselves at the expense of MPT and its shareholders. The lawsuit is available here.

Although Perring has publicly acknowledged the lawsuit, he has not appeared in the case. And rather than answer MPT’s allegations, Viceroy has filed motions to dismiss the claims before they reach a jury, arguing that they cannot be sustained because Viceroy’s assaults on the Company, though contained in “reports,” were not “fact” but mere “opinion” and “commentary . . . dominated by colorful, hyperbolic language,” and also claiming that the Court lacks jurisdiction. But as MPT’s complaint makes clear, the false, misleading, and defamatory statements repeatedly published by Viceroy, Perring and others are not “opinions” or “beliefs” but rather statements of purported fact, whose fundamental character cannot be altered by disclaimers. MPT looks forward to proving its claims and to obtaining from the defendants and others the documents, communications, and other discovery to which the law entitles it.

CONFERENCE CALL AND WEBCAST

The Company has scheduled a conference call and webcast for Thursday, April 27, 2023 at 11:00 a.m. Eastern Time to present the Company’s financial and operating results for the quarter ended March 31, 2023. The dial-in numbers for the conference call are 833-630-1956 (U.S.) and 412-317-1837 (International); there is no passcode requirement. Call participants are to ask the operator to be joined to the Medical Properties Trust, Inc. conference call upon dialing in. The conference call will also be available via webcast in the Investor Relations section of the Company’s website, www.medicalpropertiestrust.com.

A telephone and webcast replay of the call will be available beginning shortly after the call’s completion. The telephone replay will be available through May 11, 2023 using dial-in numbers 877-344-7529 (U.S.), 855-669-9658 (Canada) and 412-317-0088 (International) along with passcode 5178516. The webcast replay will be available for one year following the call’s completion on the Investor Relations section of the Company’s website.

The Company’s supplemental information package for the current period will also be available on the Company’s website in the Investor Relations section.

The Company uses, and intends to continue to use, the Investor Relations page of its website, which can be found at www.medicalpropertiestrust.com, as a means of disclosing material nonpublic information and of complying with its disclosure obligations under Regulation FD, including, without limitation, through the posting of investor presentations that may include material nonpublic information. Accordingly, investors should monitor the Investor Relations page, in addition to following our press releases, SEC filings, public conference calls, presentations and webcasts. The information contained on, or that may be accessed through, our website is not incorporated by reference into, and is not a part of, this document.

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About Medical Properties Trust, Inc.

Medical Properties Trust, Inc. is a self-advised real estate investment trust formed in 2003 to acquire and develop net-leased hospital facilities. From its inception in Birmingham, Alabama, the Company has grown to become one of the world’s largest owners of hospital real estate with 444 facilities and approximately 45,000 licensed beds in ten countries and across four continents. MPT’s financing model facilitates acquisitions and recapitalizations and allows operators of hospitals to unlock the value of their real estate assets to fund facility improvements, technology upgrades and other investments in operations. For more information, please visit the Company’s website at www.medicalpropertiestrust.com.

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements can generally be identified by the use of forward-looking words such as “may”, “will”, “would”, “could”, “expect”, “intend”, “plan”, “estimate”, “target”, “anticipate”, “believe”, “objectives”, “outlook”, “guidance” or other similar words, and include statements regarding our strategies, objectives, future expansion and development activities, and expected financial performance. Forward-looking statements involve known and unknown risks and uncertainties that may cause our actual results or future events to differ materially from those expressed in or underlying such forward-looking statements, including, but not limited to: (i) the economic, political and social impact of, and uncertainty relating to, potential impact from health crises (like COVID-19); (ii) the ability of our tenants, operators and borrowers to satisfy their obligations under their respective contractual arrangements with us, especially as a result of the adverse economic impact of the COVID-19 pandemic, and government regulation of hospitals and healthcare providers in connection with same (as further detailed in our Current Report on Form 8-K filed with the SEC on April 8, 2020); (iii) our expectations regarding annual guidance for net income and NFFO per share; (iv) our success in implementing our business strategy and our ability to identify, underwrite, finance, consummate and integrate acquisitions and investments; (v) the nature and extent of our current and future competition; (vi) macroeconomic conditions, such as a disruption of or lack of access to the capital markets or movements in currency exchange rates; (vii) our ability to obtain debt financing on attractive terms or at all, which may adversely impact our ability to pursue acquisition and development opportunities and pay down, refinance, restructure or extend our indebtedness as it becomes due; (viii) increases in our borrowing costs as a result of changes in interest rates and other factors; (ix) international, national and local economic, real estate and other market conditions, which may negatively impact, among other things, the financial condition of our tenants, lenders and institutions that hold our cash balances, and may expose us to increased risks of default by these parties; (x) factors affecting the real estate industry generally or the healthcare real estate industry in particular; (xi) our ability to maintain our status as a REIT for federal and state income tax purposes; (xii) federal and state healthcare and other regulatory requirements, as well as those in the foreign jurisdictions where we own properties; (xiii) the value of our real estate assets, which may limit our ability to dispose of assets at attractive prices or obtain or maintain equity or debt financing secured by our properties or on an unsecured basis; (xiv) the ability of our tenants and operators to operate profitably and generate positive cash flow, comply with applicable laws, rules and regulations in the operation of the our properties, to deliver high-quality services, to attract and retain qualified personnel and to attract patients; (xv) potential environmental contingencies and other liabilities; (xvi) the risk that the expected sale of three Connecticut hospitals currently leased to Prospect does not occur; (xvii) the risk that Steward’s anticipated sale of its Utah operations and MPT’s expected lease with CommonSpirit Health are not executed as announced; (xviii) the risk that MPT’s expected sale of its Australian portfolio does not occur; (xix) the risk that other property sales, loan repayments, and other capital recycling transactions do not occur; and (xx) the risks and uncertainties of litigation, including our lawsuit against Viceroy Research LLC and its principals.

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The risks described above are not exhaustive and additional factors could adversely affect our business and financial performance, including the risk factors discussed under the section captioned “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2022 and as updated in our quarterly reports on Form 10-Q. Forward-looking statements are inherently uncertain and actual performance or outcomes may vary materially from any forward-looking statements and the assumptions on which those statements are based. Readers are cautioned to not place undue reliance on forward-looking statements as predictions of future events. We disclaim any responsibility to update such forward-looking statements, which speak only as of the date on which they were made.

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MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Consolidated Balance Sheets

(A) Financials have been derived from the prior year audited financial statements.

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Consolidated Statements of Income

(Unaudited)

(A) Includes $4.2 million and $6.3 million of ground lease and other expenses (such as property taxes and insurance) paid directly by us and reimbursed by our tenants for the three months ended March 31, 2023 and 2022, respectively.

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

Reconciliation of Net Income to Funds From Operations

(Unaudited)

Notes:

(A) Certain line items above (such as depreciation and amortization) include our share of such income/expense from unconsolidated joint ventures. These amounts are included with all activity of our equity interests in the “Earnings from equity interests” line on the consolidated statements of income.

(B) Investors and analysts following the real estate industry utilize funds from operations (“FFO”) as a supplemental performance measure. FFO, reflecting the assumption that real estate asset values rise or fall with market conditions, principally adjusts for the effects of GAAP depreciation and amortization of real estate assets, which assumes that the value of real estate diminishes predictably over time. We compute FFO in accordance with the definition provided by the National Association of Real Estate Investment Trusts, or Nareit, which represents net income (loss) (computed in accordance with GAAP), excluding gains (losses) on sales of real estate and impairment charges on real estate assets, plus real estate depreciation and amortization, including amortization related to in-place lease intangibles, and after adjustments for unconsolidated partnerships and joint ventures.

In addition to presenting FFO in accordance with the Nareit definition, we disclose normalized FFO, which adjusts FFO for items that relate to unanticipated or non-core events or activities or accounting changes that, if not noted, would make comparison to prior period results and market expectations less meaningful to investors and analysts. We believe that the use of FFO, combined with the required GAAP presentations, improves the understanding of our operating results among investors and the use of normalized FFO makes comparisons of our operating results with prior periods and other companies more meaningful. While FFO and normalized FFO are relevant and widely used supplemental measures of operating and financial performance of REITs, they should not be viewed as a substitute measure of our operating performance since the measures do not reflect either depreciation and amortization costs or the level of capital expenditures and leasing costs (if any not paid by our tenants) to maintain the operating performance of our properties, which can be significant economic costs that could materially impact our results of operations. FFO and normalized FFO should not be considered an alternative to net income (loss) (computed in accordance with GAAP) as indicators of our results of operations or to cash flow from operating activities (computed in accordance with GAAP) as an indicator of our liquidity.

We calculate adjusted funds from operations, or AFFO, by subtracting from or adding to normalized FFO (i) straight-line rent, (ii) non-cash share-based compensation expense, and (iii) amortization of deferred financing costs. AFFO is an operating measurement that we use to analyze our results of operations based more on the receipt, rather than the accrual, of our rental revenue and on certain other adjustments. We believe that this is an important measurement because our infrastructure-type assets generally require longer term leases with annual contractual escalations of base rents, resulting in the recognition of a significant amount of rental income that is not billable/collected until future periods. Our calculation of AFFO may not be comparable to AFFO or similarly titled measures reported by other REITs. AFFO should not be considered as an alternative to net income (calculated pursuant to GAAP) as an indicator of our results of operations or to cash flow from operating activities (calculated pursuant to GAAP) as an indicator of our liquidity.

MEDICAL PROPERTIES TRUST, INC. AND SUBSIDIARIES

2023 Guidance Reconciliation

(Unaudited)

(1) The guidance is based on current expectations and actual results or future events may differ materially from those expressed in this table, which is a forward-looking statement within the meaning of the federal securities laws. Please refer to the forward-looking statement included in this press release and our filings with the Securities and Exchange Commission for a discussion of risk factors that affect our performance.

Exhibit 99.2

QUARTERLY SUPPLEMENTAL FIRST QUARTER 2023

FORWARD-LOOKING STATEMENTS COMPANY OVERVIEW Forward-looking statements involve known and unknown 3 risks, uncertainties and other factors that may cause the actual results of the Company or future events to differ Company Information 3 materially from those expressed in or underlying such forward-looking statements, including without limitation: Normalized FFO per share; expected payout ratio; the amount of acquisitions of healthcare real estate, if any; Net FINANCIAL INFORMATION Debt to EBITDAre; portfolio diversification; capital markets conditions; the repayment of debt arrangements; state- Reconciliation of Net Income to Funds from Operations 6 ments concerning the additional income to the Company as a result of ownership interests in certain hospital operations 6 Debt Summary 7 and the timing of such income; the payment of future dividends, if any; completion of additional debt arrangements Debt Maturities and Debt Metrics 8 and additional investments; national and international economic, business, regulatory, real estate and other market conditions; the competitive environment in which the Company operates; the execution of the Company’s business PORTFOLIO INFORMATION plan; financing risks; the Company’s ability to maintain its status as a REIT for federal income tax purposes; acquisition Lease and Loan Maturity Schedule 9 and development risks; potential environmental and other liabilities; potential impact from health crises (like COVID-19) Total Assets and Revenues and the risks and uncertainties of litigation, including our 9 lawsuit against Viceroy Research and its principals, and by Asset Type, Operator, State and Country 10 other events beyond the control of our tenants/borrowers and the related impact to us; and other factors affecting the Rent Coverage 13 real estate industry generally or healthcare real estate in particular. For further discussion of the factors that could Summary of Investments and Development Projects 15 affect outcomes, please refer to the “Risk Factors” section of the Company’s Annual Report on Form 10-K for the year ended December 31, 2022, and as updated by the Compa- FINANCIAL STATEMENTS ny’s subsequently filed Quarterly Reports on Form 10-Q and other SEC filings. Except as otherwise required by the federal securities laws, the Company undertakes no obligation to Consolidated Statements of Income 16 update the information in this report. Consolidated Balance Sheets 17 Certain information in the supplemental package may be shown adjusted for transactions completed subsequent to 16 period end and the consummation of pending transactions, Investments in Unconsolidated Real Estate including the expected sale of three Connecticut hospitals Joint Ventures 18 currently leased to Prospect, the expected purchase of Steward’s Utah operations by CommonSpirit Health, the Investments in Unconsolidated Operating Entities 19 expected sale of our Australia portfolio, and the expected repurchase of three hospitals by Prime. The adjustments are based upon available information and assumptions that Appendix—Non-GAAP Reconciliations 20-21 we believe are reasonable. There is no assurance that any pending transactions will occur. On the cover and below: Jordan Valley Medical Center in West Jordan, Utah – expected to be occupied beginning in May 2023 by CommonSpirit Health, the largest Catholic health system in the United States.

COMPANY OVERVIEW M edical Properties Trust, Inc. is a self-advised MPT’s financing model facilitates acquisitions real estate investment trust formed in 2003 and recapitalizations and allows operators to acquire and develop net-leased hospital facilities. of hospitals to unlock the value of their real From its inception in Birmingham, Alabama, the estate assets to fund facility improvements, Company has grown to become one of the world’s technology upgrades and other investments largest owners of hospital real estate. in operations. of March 31, 2023. 444 54 ~45,000 31 10 properties operators beds U.S. states countries MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 3

MPT Officers Edward K. Aldag, Jr. Chairman, President and Chief Executive Officer R. Steven Hamner Executive Vice President and Chief Financial Officer Emmett E. McLean Executive Vice President, Chief Operating Officer and Secretary J. Kevin Hanna Senior Vice President, Controller and Chief Accounting Officer Rosa H. Hooper Senior Vice President of Operations & Assistant Secretary Larry H. Portal Senior Vice President, Senior Advisor to the CEO (not pictured) Charles R. Lambert Vice President, Treasurer and Managing Director of Capital Markets R. Lucas Savage Vice President, Head of Global Acquisitions From the Left: Charles R. Lambert, Emmett E. McLean, R. Lucas Savage, Edward K. Aldag, Jr., R. Steven Hamner, Rosa H. Hooper and J. Kevin Hanna (not pictured: Larry H. Portal). Board of Directors Corporate Headquarters Edward K. Aldag, Jr. G. Steven Dawson Medical Properties Trust, Inc. R. Steven Hamner 1000 Urban Center Drive, Suite 501 Caterina A. Mozingo Birmingham, AL 35242 Emily W. Murphy Elizabeth N. Pitman (205) 969-3755 D. Paul Sparks, Jr. (205) 969-3756 (fax) Michael G. Stewart www.medicalpropertiestrust.com C. Reynolds Thompson, III MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 4

INVESTOR RELATIONS Drew Babin Tim Berryman Senior Managing Director of Corporate Communications Managing Director of Investor Relations (646) 884-9809 dbabin@medicalpropertiestrust.com (205) 397-8589 tberryman@medicalpropertiestrust.com Stock Exchange Senior Transfer Listing and Unsecured Agent Trading Symbol Debt Ratings American Stock Transfer New York Stock Exchange Moody’s: Ba1 and Trust Company (NYSE): MPW Standard & Poor’s: BB+ 6201 15th Avenue Brooklyn, NY 11219 GenesisCare Campo de Gibraltar—Algeciras, Cádiz, Spain. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 5

FINANCIAL INFORMATION RECONCILIATION OF NET INCOME TO FUNDS FROM OPERATIONS (Unaudited) (Amounts in thousands, except per share data) For the Three Months Ended March 31, 2023 March 31, 2022 FFO INFORMATION: Net income attributable to MPT common stockholders $ 32,794 $ 631,681 Participating securities’ share in earnings (515) (402) Net income, less participating securities’ share in earnings $ 32,279 $ 631,279 Depreciation and amortization 101,960 99,459 Gain on sale of real estate (62) (451,638) Real estate impairment charges 52,104 —Funds from operations $ 186,281 $ 279,100 Write-off (recovery) of unbilled rent and other 39,626 (2,271) Other impairment charges — 4,875 Litigation and other 7,726 -Non-cash fair value adjustments (4,121) (8,023) Tax rate changes and other (7,305) -Debt refinancing and unutilized financing costs — 8,816 Normalized funds from operations $ 222,207 $ 282,497 Share-based compensation 11,829 11,804 Debt costs amortization 5,121 5,613 Rent deferral, net 2,413 (3,716) Straight-line rent revenue and other (62,589) (77,333) Adjusted funds from operations $ 178,981 $ 218,865 PER DILUTED SHARE DATA: Net income, less participating securities’ share in earnings $ 0.05 $ 1.05 Depreciation and amortization 0.17 0.17 Gain on sale of real estate — (0.75) Real estate impairment charges 0.09 —Funds from operations $ 0.31 $ 0.47 Write-off (recovery) of unbilled rent and other 0.07 -Other impairment charges — -Litigation and other 0.01 -Non-cash fair value adjustments (0.01) (0.01) Tax rate changes and other (0.01) -Debt refinancing and unutilized financing costs — 0.01 Normalized funds from operations $ 0.37 $ 0.47 Share-based compensation 0.02 0.02 Debt costs amortization 0.01 0.01 Rent deferral, net — (0.01) Straight-line rent revenue and other (0.10) (0.12) Adjusted funds from operations $ 0.30 $ 0.37 Notes: (A) Certain line items above (such as depreciation and amortization) include our share of such income/expense from unconsolidated joint ventures. These amounts are included with all activity of our equity interests in the “Earnings from equity interests” line on the consolidated statements of income. (B) Investors and analysts following the real estate industry utilize funds from operations (“FFO”) as a supplemental performance measure. FFO, reflecting the assumption that real estate asset values rise or fall with market conditions, principally adjusts for the effects of GAAP depreciation and amortization of real estate assets, which assumes that the value of real estate diminishes predictably over time. We compute FFO in accordance with the definition provided by the National Association of Real Estate Investment Trusts, or Nareit, which represents net income (loss) (computed in accordance with GAAP), excluding gains (losses) on sales of real estate and impairment charges on real estate assets, plus real estate depreciation and amortization, including amortization related to in-place lease intangibles, and after adjustments for unconsolidated partnerships and joint ventures. In addition to presenting FFO in accordance with the Nareit definition, we disclose normalized FFO, which adjusts FFO for items that relate to unanticipated or non-core events or activities or accounting changes that, if not noted, would make comparison to prior period results and market expectations less meaningful to investors and analysts. We believe that the use of FFO, combined with the required GAAP presentations, improves the understanding of our operating results among investors and the use of normalized FFO makes comparisons of our operating results with prior periods and other companies more meaningful. While FFO and normalized FFO are relevant and widely used supplemental measures of operating and financial performance of REITs, they should not be viewed as a substitute measure of our operating performance since the measures do not reflect either depreciation and amortization costs or the level of capital expenditures and leasing costs (if any not paid by our tenants) to maintain the operating performance of our properties, which can be significant economic costs that could materially impact our results of operations. FFO and normalized FFO should not be considered an alternative to net income (loss) (computed in accordance with GAAP) as indicators of our results of operations or to cash flow from operating activities (computed in accordance with GAAP) as an indicator of our liquidity. We calculate adjusted funds from operations, or AFFO, by subtracting from or adding to normalized FFO (i) straight-line rent, (ii) non-cash share-based compensation expense, and (iii) amortization of deferred financing costs. AFFO is an operating measurement that we use to analyze our results of operations based more on the receipt, rather than the accrual, of our rental revenue and on certain other adjustments. We believe that this is an important measurement because our infrastructure-type assets generally require longer term leases with annual contractual escalations of base rents, resulting in the recognition of a significant amount of rental income that is not billable/collected until future periods. Our calculation of AFFO may not be comparable to AFFO or similarly titled measures reported by other REITs. AFFO should not be considered as an alternative to net income (calculated pursuant to GAAP) as an indicator of our results of operations or to cash flow from operating activities (calculated pursuant to GAAP) as an indicator of our liquidity. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 6

FINANCIAL INFORMATION (As of March 31, 2023) ($ amounts in thousands) DEBT SUMMARY Debt Instrument Rate Type Rate Balance 2026 Credit Facility Revolver(A) Variable 4.115%—6.409% $ 1,031,037 2027 Term Loan Variable 6.607% 200,000 2.550% Notes Due 2023 (Ł400M)(A) Fixed 2.550% 493,480 2024 AUD Term Loan (A$1.2B)(A) Fixed(B) 2.850% 802,200 2024 GBP Term Loan (Ł105M)(A) Fixed 5.250% 129,353 3.325% Notes Due 2025 (€500M)(A) Fixed 3.325% 541,950 2025 GBP Term Loan (Ł700M)(A) Fixed(C) 2.349% 863,590 0.993% Notes Due 2026 (€500M)(A) Fixed 0.993% 541,950 5.250% Notes Due 2026 Fixed 5.250% 500,000 2.500% Notes Due 2026 (Ł500M)(A) Fixed 2.500% 616,850 5.000% Notes Due 2027 Fixed 5.000% 1,400,000 3.692% Notes Due 2028 (Ł600M)(A) Fixed 3.692% 740,220 4.625% Notes Due 2029 Fixed 4.625% 900,000 3.375% Notes Due 2030 (Ł350M)(A) Fixed 3.375% 431,795 3.500% Notes Due 2031 Fixed 3.500% 1,300,000 $ 10,492,425 Debt issuance costs and discount (54,274) Weighted average rate 3.796% $ 10,438,151 RATE TYPE AS PERCENTAGE OF TOTAL DEBT Variable 12% Fixed 88% (A) Non-USD denominated debt converted to U.S. dollars at March 31, 2023. (B) We entered into an interest rate swap transaction, effective July 3, 2019, to fix the benchmark variable interest rate of the loan. On March 10, 2023, the rate increased to 2.850%. (C) We entered into an interest rate swap transaction, effective March 6, 2020, to fix the benchmark variable interest rate of the loan. On March 10, 2023, the rate increased to 2.349%. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 7

FINANCIAL INFORMATION (As of March 31, 2023) ($ amounts in thousands) DEBT MATURITIES Senior Unsecured Year Term Loans/Revolver Total Debt % of Total Notes 2023 $ 493,480 $ —$ 493,480 4.7% 2024 — 931,553 931,553 8.9% 2025 541,950 863,590 1,405,540 13.4% 2026 1,658,800 1,031,037 2,689,837 25.6% 2027 1,400,000 200,000 1,600,000 15.2% 2028 740,220 — 740,220 7.1% 2029 900,000 — 900,000 8.6% 2030 431,795 — 431,795 4.1% 2031 1,300,000 — 1,300,000 12.4% Totals $ 7,466,245 $ 3,026,180 $ 10,492,425 100.0% DEBT BY LOCAL CURRENCY Senior Unsecured Term Loans/Revolver Total Debt % of Total Notes United States $ 4,100,000 $ 810,000 $ 4,910,000 46.8% United Kingdom 2,282,345 1,139,753 3,422,098 32.6% Australia — 802,200 802,200 7.7% Europe 1,083,900 274,227 1,358,127 12.9% Totals $ 7,466,245 $ 3,026,180 $ 10,492,425 100.0% DEBT METRICS For the Three Months Ended March 31, 2023 Adjusted Net Debt to Annualized EBITDAre Ratios: Adjusted Net Debt $ 9,772,836 Adjusted Annualized EBITDAre 1,350,508 Adjusted Net Debt to Annualized EBITDAre Ratio 7.2x Transaction Adjusted Net Debt $ 8,365,636 Transaction Adjusted Annualized EBITDAre 1,283,788 Transaction Adjusted Net Debt to Annualized EBITDAre Ratio 6.5x Leverage Ratio: Unsecured Debt $ 10,363,072 Secured Debt 129,353 Total Debt $ 10,492,425 Total Gross Assets 20,857,856 Financial Leverage 50.3% Interest Coverage Ratios: Interest Expense $ 97,654 Capitalized Interest 2,914 Debt Costs Amortization (4,014) Total Interest $ 96,554 EBITDAre 282,567 Interest Coverage Ratio 2.9x Adjusted EBITDAre $ 337,627 Adjusted Interest Coverage Ratio 3.5x See appendix for reconciliation from net income to Adjusted EBITDAre and Transaction Adjusted EBITDAre and Transaction Adjusted Net Debt. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 8

PORTFOLIO INFORMATION LEASE AND LOAN MATURITY SCHEDULE (A) ($ amounts in thousands) (B) (C) (D) Percentage of Total Years of Maturities Total Properties Base Rent/Interest Base Rent/Interest 2023 (E) 14 $ 59,616 4.3% 2024 2 4,523 0.3% 2025 7 19,837 1.4% 2026 4 2,490 0.2% 2027 1 3,476 0.3% 2028 4 5,998 0.4% 2029 5 12,391 0.9% 2030 11 6,454 0.5% 2031 4 4,746 0.3% 2032 41 68,373 5.0% Thereafter 339 1,183,966 86.4% 432 $ 1,371,870 100.0% Percentage of total base rent/interest 100% 90% 86.4% 80% 70% 60% 50% 40% 30% 20% 10% 4.3% 5.0% 0.3% 1.4% 0.2% 0.3% 0.4% 0.9% 0.5% 0.3% 0% (A) Schedule includes leases and mortgage loans. (B) Lease/Loan expiration is based on the fixed term of the lease/loan and does not factor in potential renewal or other options provided for in our agreements. (C) Reflects all properties, including those that are part of joint ventures, except vacant properties (representing less than 0.3% of total assets), and seven facilities that are under development. (D) Represents contractual base rent/interest income on an annualized basis as of period end (including foreign currency exchange rates) but does not include tenant recoveries, additional rents and other lease-related adjustments to revenue (i.e., straight-line rents and deferred revenues). (E) Properties classified as held for sale are shown to mature in current year, including 11 facilities currently leased to Healthscope and three facilities currently leased to Prime. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 9

PORTFOLIO INFORMATION TOTAL ASSETS AND REVENUES BY ASSET TYPE (March 31, 2023) ($ amounts in thousands) Total Percentage of Q1 2023 Percentage of Asset Types Properties (A) (B) Assets Total Assets Revenues Q1 2023 Revenues General Acute Care Hospitals 202 $ 13,468,942 68.5% $ 253,036 72.3% Behavioral Health Facilities 67 2,548,619 13.0% 53,658 15.3% Inpatient Rehabilitation Facilities 112 1,411,158 7.2% 29,046 8.3% Long-Term Acute Care Hospitals 20 276,740 1.4% 8,251 2.4% Freestanding ER/Urgent Care Facilities 43 235,306 1.2% 6,220 1.7% Other — 1,709,392 8.7% — —Total 444 $ 19,650,157 100.0% $ 350,211 100.0% TOTAL ASSETS BY ASSET TYPE TOTAL REVENUES BY ASSET TYPE 9% 2% 1% 3% 1% 7% General Acute Care Hospitals 8% Behavioral Health Facilities 15% 13% Inpatient Rehabilitation Facilities 72% 69% Long-Term Acute Care Hospitals Freestanding ER/Urgent Care Facilitie Other DOMESTIC ASSETS BY ASSET TYPE DOMESTIC REVENUES BY ASSET TYPE 9% 4% 3% 2% 2% General Acute Care Hospitals 9% 6% Behavioral Health Facilities 10% 8% Inpatient Rehabilitation Facilities 73% Long-Term Acute Care Hospitals 74% Freestanding ER/Urgent Care Facilities Other (A) Agrees to total assets on our consolidated balance sheets. (B) Reflects actual revenues on our consolidated statements of income. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 10

PORTFOLIO INFORMATION TOTAL ASSETS—LARGEST INDIVIDUAL FACILITY (March 31, 2023) COMPREHENSIVE PROPERTY-LEVEL UNDERWRITING FRAMEWORK Largest Individual MPT invests in real estate, not the consolidated financial performance of its tenants. Operators Facility as a Percentage Each facility is underwritten for characteristics that make the infrastructure of Total Assets(A) attractive to any experienced, competent operator—not just the current tenant. If we have underwritten these correctly, then coupled with our absolute net master Steward Health Care 2.6% lease structure, our real estate will be attractive to a replacement operator, in the 1.2% rare event we must transition. Such underwriting characteristics include: Prospect Medical Holdings Circle Health 1.0% Priory Group 0.6% Springstone 0.4% Physical Quality Competition 49 operators 1.3% Largest Individual Facility Investment is Less Than 3% of MPT Investment Portfolio Demographics Financial and Market TOTAL ASSETS AND REVENUES BY OPERATOR (March 31, 2023) ($ amounts in thousands) Total Percentage of Q1 2023 Percentage of Operators(C) Properties (A) (B) Assets Total Assets Revenues Q1 2023 Revenues Steward Health Care 41 Florida market $ 1,319,878 6.7% $ 26,181 7.5% Utah market 1,186,838 6.0% 34,601 9.9% Texas/Arkansas/Louisiana market 1,119,380 5.7% 23,452 6.7% Massachusetts market 758,718 3.9% 6,649 1.9% Arizona market 296,550 1.5% 8,905 2.5% Ohio/Pennsylvania market 119,230 0.6% 3,706 1.1% Circle Health 36 2,092,822 10.7% 47,415 13.5% Prospect Medical Holdings 14 1,533,412 7.8% —0.0% Priory Group 32 1,310,968 6.7% 24,740 7.1% Springstone 19 796,248 4.0% 20,167 5.8% Healthscope 11 781,585 4.0% 15,237 4.4% Swiss Medical Network 17 763,711 3.9% 1,196 0.3% Ernest Health, Inc. 29 608,301 3.1% 16,170 4.6% MEDIAN 78 592,249 3.0% 6,533 1.9% Prime Healthcare 12 570,537 2.9% 19,038 5.4% 44 operators 155 4,090,338 20.8% 96,221 27.4% Other — 1,709,392 8.7% — — Total 444 $ 19,650,157 100.0% $ 350,211 100.0% (A) Agrees to total assets on our consolidated balance sheets. (B) Reflects actual revenues on our consolidated statements of income. (C) On an adjusted gross asset basis comparable to our presentation in the SupplementalUpdate for the fourth quarter of 2022, and after adjusting for the expected sale of 11 Australia properties currently leased to Healthscope, the expected sale of three Connecticut hospitals currently leased to Prospect, the expected purchase of Steward’s Utah operations by CommonSpirit Health, and the expected repurchase of three hospitals by Prime, the concentration for Steward, Circle, Prospect, Priory, and Springstone would be 20.8%, 11.0%, 5.8%, 6.6%, and 4.0%, respectively, at March 31, 2023. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 11

PORTFOLIO INFORMATION TOTAL ASSETS AND REVENUES BY U.S. STATE AND COUNTRY (March 31, 2023) ($ amounts in thousands) Total Percentage of Q1 2023 Percentage of U.S. States and Other Countries Properties (A) (B) Assets Total Assets Revenues Q1 2023 Revenues Texas 52 $ 2,008,146 10.2% $ 44,116 12.6% California 20 1,502,060 7.7% 19,495 5.6% Florida 9 1,319,878 6.7% 26,182 7.5% Utah 7 1,218,883 6.2% 35,641 10.2% Massachusetts 10 763,555 3.9% 6,816 1.8% 26 Other States 122 4,035,762 20.5% 99,137 28.4% Other — 1,087,136 5.5% — —United States 220 $ 11,935,420 60.7% $ 231,387 66.1% United Kingdom 87 $ 4,145,170 21.1% $ 84,206 24.0% Australia 11 781,585 4.0% 15,237 4.4% Switzerland 17 763,711 3.9% 1,196 0.3% Germany 82 666,930 3.4% 8,551 2.4% Spain 9 226,800 1.1% 2,040 0.6% Other Countries 18 508,285 2.6% 7,594 2.2% Other — 622,256 3.2% — —International 224 $ 7,714,737 39.3% $ 118,824 33.9% Total 444 $ 19,650,157 100.0% $ 350,211 100.0% (A) Agrees to total assets on our consolidated balance sheets. (B) Reflects actual revenues on our consolidated statements of income. TOTAL ASSETS BY COUNTRY TOTAL REVENUES BY COUNTRY 3% 3% 1% 2% 2%1% 1% United States 4% 3% 4%4% United Kingdom Australia 24% Switzerland 61% 21% 66% Germany Spain Other Countries Other ASSETS BY U.S. STATE REVENUES BY U.S. STATE 5% Texas 10% California 13% Florida 8% 28% 21% Utah 6% Massachusetts 7% 7% 26 Other States 4% 6% 2% 10% Other MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 12

PORTFOLIO INFORMATION TOTAL PORTFOLIO TTM EBITDARM(A)(B) RENT COVERAGE INCLUSIVE OF ALL CARES ACT GRANTS YOY AND SEQUENTIAL QUARTER COMPARISONS BY PROPERTY TYPE Notes: All data presented is on a trailing twelve month basis. For properties acquired in the preceding twelve months, data is for the period between MPT acquisition and December 31, 2022. (A) EBITDARM is facility-level earnings before interest, taxes, depreciation, amortization, rent and management fees. EBITDARM includes normal GAAP expensed maintenance and repair costs. EBITDARM does not give effect for capitalized expenditures that extend the life or improve the facility and equipment in a way to drive more future revenues. The majority of these types of capital expenditures are financed and do not have an immediate cash impact. MPT’s rent is not subordinate to capitalized expenses. In addition, EBITDARM does not represent property net income or cash flows from operations and should not be considered an alternative to those indicators. EBITDARM figures utilized in calculating coverages presented are based on financial information provided by MPT’s tenants. MPT has not independently verified this information, but has no reason to believe this information is inaccurate in any material respect. TTM Coverages are calculated based on actual, unadjusted EBITDARM results as presented in tenant financial reporting and cash rent paid to MPT, except as noted below. —Total CARES Act Grants received by tenants during the period between March 2020 and June 2021 have been spread evenly by quarter from Q2 2020 through Q2 2021. Any additional grants received after June 2021 are included in the quarter that they were recorded by the tenant. (B) General Acute Care coverages and Total Portfolio coverages do not include Pipeline Health facilities as Pipeline Health filed Chapter 11 bankruptcy in October 2022, do not include Healthscope facilities due to pending sale, and do not include Prospect Medical Holdings due to restructuring. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 13

PORTFOLIO INFORMATION TOTAL PORTFOLIO TTM EBITDARM RENT COVERAGE INCLUSIVE OF ALL CARES ACT GRANTS EBITDARM RENT COVERAGE: OPERATORS WITH PROPERTY-LEVEL REPORTING Net Investment Tenant (A) Primary Property Type TTM EBITDARM Rent Coverage (in thousands) Steward Health Care $ 3,530,257 General Acute 2.6x Priory Group 850,574 Behavioral 2.2x Prospect Medical Holdings(B) 663,256 General Acute 1.0x MEDIAN 592,249 IRF 1.6x Prime Healthcare 570,537 General Acute 3.0x Ernest Health 544,629 IRF/LTACH 2.4x Vibra Healthcare 244,682 IRF/LTACH 2.1x Aspris Children’s Services 240,032 Behavioral 2.3x Surgery Partners 162,785 General Acute 7.3x Ardent Health Services 87,909 General Acute 6.6x Other Reporting Tenants 632,396 Various 2.7x Total $ 8,119,306 2.5x Net Investment Tenant (A) Primary Property Type TTM EBITDARM Rent Coverage (in thousands) International Operator 1 $ 2,042,134 General Acute 2.2x Domestic Operator 1 512,331 General Acute 1.1x Domestic Operator 2 390,833 General Acute/LTACH 1.0x Domestic Operator 3 777,006 Behavioral 1.4x Total $ 3,722,304 1.7x PROPERTY-LEVEL REPORTING NOT REQUIRED AND/OR NOT AVAILABLE Net Investment Tenant (A) Primary Property Type Comments (in thousands) Swiss Medical Network $ 527,665 General Acute Second largest group of private hospitals in Switzerland One of largest health care operators in the world; Parent guaranty; Ramsay Health Care UK 397,850 General Acute Investment grade-rated Pihlajalinna 220,581 General Acute Finland’s leading provider of social and health services Saint Luke’s—Kansas City 130,123 General Acute Investment grade-rated NHS 87,483 General Acute Single-payor government entity in UK Dignity Health 44,299 General Acute Part of CommonSpirit Health; Parent guaranty; Investment grade-rated Largest private hospital system in Portugal with 20 facilities and 75+ year CUF 30,120 General Acute operating history NeuroPsychiatric Hospitals 27,246 Behavioral Parent guaranty Community Health Systems 26,895 General Acute U.S. hospital operator with substantial operating history Other Tenants 24,994 General Acute N/A Total $ 1,517,256 Above data represents approximately 88% of MPT Total Real Estate Investment (C) Notes: All data presented is on a trailing twelve month basis. For properties acquired in the preceding twelve months, data is for the period between MPT acquisition and December 31, 2022. (A) Investment figures exclude equity investments, non-real estate loans, freestanding ER/urgent care facilities, and facilities under development. (B) Prospect Medical Holdings coverage includes California facilities only. (C) Healthscope and Prospect Connecticut are excluded due to pending sale. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 14

PORTFOLIO INFORMATION SUMMARY OF INVESTMENTS (For the three months ended March 31, 2023) (Amounts in thousands) Operator Location Investment(A) Commencement Date PHP Holdings California $ 50,000 Q1 2023 Capital Additions, Development and (B) Various 47,441 Various Other Funding for Existing Tenants $ 97,441 SUMMARY OF CURRENT DEVELOPMENT PROJECTS AS OF MARCH 31, 2023 (Amounts in thousands) Costs Incurred as of Estimated Commencement Operator Location Commitment March 31, 2023 Date Ernest Health California $ 47,700 $ 46,372 Q2 2023 IMED Hospitales Spain 51,043 13,323 Q2 2023 Ernest Health South Carolina 22,400 14,469 Q3 2023 IMED Hospitales Spain 45,976 37,568 Q3 2023 Springstone Texas 31,600 4,099 Q1 2024 IMED Hospitales Spain 37,193 9,170 Q3 2024 Steward Health Care Texas 169,408 57,059 Q1 2026 $ 405,320 $ 182,060 (A) Excludes transaction costs, such as real estate transfer and other taxes. Amount assumes exchange rate as of the investment date. (B) Reflects normal capital additions that extend the life or improve existing facilities on which we receive a return equal to the lease rate for the respective facility.This includes over 10 facilities and 6 different operators. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 15

FINANCIAL STATEMENTS CONSOLIDATED STATEMENTS OF INCOME (Unaudited) (Amounts in thousands, except per share data) For the Three Months Ended March 31, 2023 March 31, 2022 REVENUES Rent billed $ 248,157 $ 263,402 Straight-line rent 56,693 61,044 Income from financing leases 13,195 51,776 Interest and other income 32,166 33,578 Total revenues 350,211 409,800 EXPENSES Interest 97,654 91,183 Real estate depreciation and amortization 83,860 85,316 Property-related(A) 7,110 8,598 General and administrative 41,724 41,424 Total expenses 230,348 226,521 OTHER (EXPENSE) INCOME Gain on sale of real estate 62 451,638 Real estate and other impairment charges (89,538) (4,875) Earnings from equity interests 11,352 7,338 Debt refinancing and unutilized financing costs — (8,816) Other (including fair value adjustments on securities) (5,166) 14,762 Total other (expense) income (83,290) 460,047 Income before income tax 36,573 643,326 Income tax expense (3,543) (11,379) Net income 33,030 631,947 Net income attributable to non-controlling interests (236) (266) Net income attributable to MPT common stockholders $ 32,794 $ 631,681 EARNINGS PER COMMON SHARE—BASIC AND DILUTED Net income attributable to MPT common stockholders $ 0 .05 $ 1 .05 WEIGHTED AVERAGE SHARES OUTSTANDING—BASIC 598,302 598,676 WEIGHTED AVERAGE SHARES OUTSTANDING—DILUTED 598,310 598,932 $ -DIVIDENDS DECLARED PER COMMON SHARE $ 0 .29 $ 0 .29 (A) Includes $4.2 million and $6.3 million of ground lease and other expenses (such as property taxes and insurance) paid directly by us and reimbursed by our tenants for the three months ended March 31, 2023 and 2022, respectively. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 16

FINANCIAL STATEMENTS CONSOLIDATED BALANCE SHEETS (Amounts in thousands, except per share data) March 31, 2023 December 31, 2022 (Unaudited) (A) ASSETS Real estate assets Land, buildings and improvements, intangible lease assets, and other $ 13,092,510 $ 13,862,415 Investment in financing leases 1,582,416 1,691,323 Real estate held for sale 881,587 -Mortgage loans 346,446 364,101 Gross investment in real estate assets 15,902,959 15,917,839 Accumulated depreciation and amortization (1,207,699) (1,193,312) Net investment in real estate assets 14,695,260 14,724,527 Cash and cash equivalents 302,321 235,668 Interest and rent receivables, net 169,511 167,035 Straight-line rent receivables 810,911 787,166 Investments in unconsolidated real estate joint ventures 1,506,474 1,497,903 Investments in unconsolidated operating entities 1,310,460 1,444,872 Other loans 276,367 227,839 Other assets 578,853 572,990 Total Assets $ 19,650,157 $ 19,658,000 LIABILITIES AND EQUITY Liabilities Debt, net $ 10,438,151 $ 10,268,412 Accounts payable and accrued expenses 595,269 621,324 Deferred revenue 29,391 27,727 Obligations to tenants and other lease liabilities 144,092 146,130 Total Liabilities 11,206,903 11,063,593 Equity Preferred stock, $0.001 par value. Authorized 10,000 shares; no shares outstanding —Common stock, $0.001 par value. Authorized 750,000 shares; issued and outstanding —598,302 shares at March 31, 2023 and 597,476 shares at December 31, 2022 598 597 Additional paid-in capital 8,541,414 8,535,140 Retained (deficit) earnings (25,413) 116,285 Accumulated other comprehensive loss (74,919) (59,184) Total Medical Properties Trust, Inc. Stockholders’ Equity 8,441,680 8,592,838 Non-controlling interests 1,574 1,569 Total Equity 8,443,254 8,594,407 Total Liabilities and Equity $ 19,650,157 $ 19,658,000 (A) Financials have been derived from the prior year audited financial statements. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 17

FINANCIAL STATEMENTS INVESTMENTS IN UNCONSOLIDATED REAL ESTATE JOINT VENTURES (As of and for the three months ended March 31, 2023) (Unaudited) ($ amounts in thousands) Swiss Medical Steward Policlinico di HM MPT Pro Rata MEDIAN(C) (D) (E) (F) (G) Total Network Health Care Monza Hospitales Share Gross real estate $ 1,907,702 $ 1,458,657 $ 1,677,587 $ 181,681 $ 366,974 $ 5,592,601 $ 3,069,683 Cash 28,964 10,753 10,990 13,893 3,611 68,211 36,076 Accumulated depreciation and amortization (205,193) (117,721) (43,156) (29,560) (25,360) (420,990) (232,771) Other assets 75,115 161,119 79,956 11,649 4,958 332,797 198,374 Total Assets $ 1,806,588 $ 1,512,808 $ 1,725,377 $ 177,663 $ 350,183 $ 5,572,619 $ 3,071,362 Debt (third party) $ 706,145 $ 676,199 $ 889,667 $ — $ 139,687 $ 2,411,698 $ 1,334,105 Other liabilities 133,030 111,131 3,573 347 85,853 333,934 184,900 Mortgage loans — 65,547 — — — 65,547 45,883 (A) Equity and shareholder loans 967,413 659,931 832,137 177,316 124,643 2,761,440 1,506,474 Total Liabilities and Equity $ 1,806,588 $ 1,512,808 $ 1,725,377 $ 177,663 $ 350,183 $ 5,572,619 $ 3,071,362 MPT share of real estate joint venture 50% 70% 50% 50% 45% Total $ 483,707 $ 461,952 $ 416,068 $ 88,658 $ 56,089 $ 1,506,474 Swiss Medical Steward Policlinico di HM MPT Pro Rata MEDIAN(C) (D) (E) (F) (G) Total Network Health Care Monza Hospitales Share Total revenues(B) $ 32,007 $ 16,681 $ 34,573 $ 4,710 $ 4,238 $ 92,209 $ 49,229 Expenses: Property-related $ 751 $ 390 $ 472 $ 1,021 $ 619 $ 3,253 $ 1,673 Interest 12,573 3,864 17,084— 522 34,043 17,768 Real estate depreciation and amortization 11,149 8,308 10,307 1,031 2,030 32,825 17,973 General and administrative 538 243 89 23 11 904 500 Gain on sale of real estate — —— — — -Income taxes 1,318 (931) — 269 656 129 Total expenses $ 26,329 $ 11,874 $ 27,952 $ 2,075 $ 3,451 $ 71,681 $ 38,043 Net Income $ 5,678 $ 4,807 $ 6,621 $ 2,635 $ 787 $ 20,528 $ 11,186 MPT share of real estate joint venture 50% 70% 50% 50% 45% (H) Earnings from equity interests $ 2,839 $ 3,365 $ 3,311 $ 1,317 $ 354 $ 11,186 (A) Includes approximately €295 million shareholder loan. (B) Includes $4.6 million of straight-line rent revenue. (C) MPT managed joint venture of 71-owned German facilities that are fully leased. (D) Represents ownership in Infracore, which owns and leases all 17 Switzerland facilities. (E) MPT managed joint venture of eight-owned Massachusetts hospital facilities that are fully leased pursuant to a master lease. (F) Represents ownership in eight Italian facilities that are fully leased. (G) Represents ownership in two Spanish facilities that are fully leased. (H) Excludes our return on our Springstone equity investment and amortization of equity investment costs. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 18

FINANCIAL STATEMENTS INVESTMENTS IN UNCONSOLIDATED OPERATING ENTITIES (Amounts in thousands) OPERATING ENTITY INVESTMENT FRAMEWORK MPT’s hospital expertise and comprehensive underwriting process allows for opportunistic investments in hospital operations. • Passive investments typically needed in order to acquire the larger real • Certain of these investments entitle us to customary minority rights and estate transactions. protections. • Cash payments go to previous owner and not to the tenant, with limited • No additional operating loss exposure beyond our investment. exceptions. • Operators are vetted as part of our overall underwriting process. • Proven track record of successful investments, including Ernest Health and Capella Healthcare. • Potential for outsized returns and organic growth. Investment Ownership Operator as of Structure Interest March 31, 2023 Loan, for which proceeds were paid to Steward’s former private equity sponsor, is secured by the equity Steward Health Care $ 362,586 N/A of Steward and provides for an initial 4% cash return plus 37% of the increase in the value of Steward over seven years. Includes our 49% equity ownership interest and a loan made for the purpose of investing in select International Joint Venture 230,153 49.0% international hospital operations. The loan carries a 7.5% interest rate and is secured by the remaining equity of the international joint venture and guaranteed by the other equity owner. In order to close the 2021 acquisition of 35 facilities, we made a 9.9% passive equity investment and a Priory 159,668 9.9% loan, proceeds of which were paid to the former owner. The loan carries a variable interest rate. Includes our passive equity ownership interest, along with a CHF 45 million loan as part of a syndicated Swiss Medical Network 158,687 10.0% loan facility. Includes our passive equity ownership interest. Proceeds from our investment were paid directly to Steward Health Care 125,862 9.9% Steward’s former private equity sponsor and other shareholders. Includes loan originated in connection with the overall $1.55 billion acquisition of 14 facilities, proceeds Prospect Medical Holdings 112,701 N/A of which were paid to the prior owner. The loan carries an interest rate of 8% and matures in 2026. The loan is secured and cross-defaulted with real estate and guaranteed by Parent. Includes our passive equity ownership interest in Aevis, a public healthcare investment company. Our Aevis 77,618 4.6% original investment of CHF 47 million is marked-to-market quarterly. As part of a capital restructuring of Prospect Medical, we made a $50 million convertible loan to PHP PHP Holdings 49,895 N/A Holdings, the managed care business of Prospect. The loan carries an 8% interest rate and is convertible into equity of PHP Holdings. Includes our passive equity ownership interest in Aspris, a spin-off of Priory’s education and children’s Aspris 16,014 9.9% services line of business. In order to close the 2021 acquisition of 18 behavioral facilities, we made an equity investment and a loan, proceeds of which were paid to the former owners of the Springstone operating entity. As a result of Springstone 10,933 20.9% Lifepoint’s acquisition of a majority interest in Springstone in February 2023, the loan and related interest (of approximately $205 million) was paid in full. We continue to hold our minority equity interest in Springstone. Includes our passive equity ownership interest in Caremax, a public care delivery system. Our original Caremax 6,343 9.9% investment is marked-to-market quarterly. Total $ 1,310,460 INVESTMENTS IN UNCONSOLIDATED OPERATING ENTITIES AS A PERCENTAGE OF TOTAL ASSETS 7% 93% MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 19

APPENDIX—NON-GAAP RECONCILIATIONS ADJUSTED NET DEBT/ANNUALIZED EBITDAre (Unaudited) (Amounts in thousands) For the Three Months Ended March 31, 2023 ADJUSTED EBITDA re RECONCILIATION Net Income $ 33,030 Add Back: Interest 97,654 Income tax 3,543 Depreciation and amortization 88,760 Gain on sale of real estate (62) Real estate and other impairment charges 52,104 Adjustment to reflect MPT’s share of unlevered EBITDAre from unconsolidated real estate joint ventures(A) 7,538 1Q 2023 EBITDAre $ 282,567 Share-based compensation 11,829 Write-off of unbilled rent and other 39,626 Litigation and other 7,726 Non-cash fair value adjustments (4,121) Annualized 1Q 2023 Adjusted EBITDAre $ 337,627 $ 1,350,508 Adjustments for mid-quarter investment activity(B) (1,461) Adjustments for post-quarter end investment activity(B) (15,219) 1Q 2023 Transaction Adjusted EBITDAre $ 320,947 $ 1,283,788 ADJUSTED NET DEBT RECONCILIATION Total debt at March 31, 2023 $ 10,438,151 Less: Cash at March 31, 2023 (302,321) Less: Cash funded for building improvements in progress and construction in progress at March 31, 2023 (362,994) Adjusted Net Debt $ 9,772,836 Adjustments for investment activity (1,407,200) Transaction Adjusted Net Debt $ 8,365,636 Investors and analysts following the real estate industry utilize net debt (debt less cash) to EBITDAre as a measurement of leverage that shows how many years it would take for us to pay back our debt, assuming net debt and EBITDAre are held constant. In our calculation, we start with EBITDAre , as defined by Nareit, which is net income before interest expense, income tax expense, depreciation and amortization, losses/gains on disposition of depreciated property, impairment losses, and adjustments to reflect our share of EBITDAre from unconsolidated real estate joint ventures. We then adjust EBITDAre for non-cash share-based compensation, non-cash fair value adjustments and other items that would make comparison of our operating results with prior periods and other companies more meaningful, to derive Adjusted EBITDAre . We adjust net debt for cash funded for building improvements in progress and construction in progress for which we are not yet receiving rent to derive Adjusted Net Debt. We further adjust Adjusted Net Debt and Adjusted EBITDAre for the effects from investments and capital transactions that were either completed during the period or disclosed as firm commitments, assuming such transactions were consummated/fully funded as of the beginning of the period to derive Transaction Adjusted Net Debt and Transaction Adjusted EBITDAre . Although non-GAAP measures, we believe Adjusted Net Debt, Transaction Adjusted Net Debt, Adjusted EBITDAre , and Transaction Adjusted EBITDAre are useful to investors and analysts as they allow for a more current view of our credit quality and allow for the comparison of our credit strength between periods and to other real estate companies without the effect of items that by their nature are not comparable from period to period. (A) Includes only the unlevered portion of our share of EBITDAre from unconsolidated real estate joint ventures, as we have excluded any net debt from our unconsolidated real estate joint ventures in the Adjusted Net Debt line. We believe this adjustment is needed to appropriately reflect the relationship between EBITDA re and net debt. (B) Adjustments to reflect the expected sale of 11 facilities in Australia, the expected sale of three Connecticut hospitals currently leased to Prospect, the expected purchase of Steward’s Utah operations by CommonSpirit Health, and a full-quarter impact from our mid-quarter investments and loan payoffs. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 20

APPENDIX—NON-GAAP RECONCILIATIONS TOTAL ADJUSTED GROSS ASSETS (Unaudited) (Amounts in thousands) March 31, 2023 Total Assets $ 19,650,157 Add: Accumulated depreciation and amortization 1,207,699 Total Gross Assets $ 20,857,856 Add: Incremental gross assets of our investments in unconsolidated real estate joint ventures(1) 1,732,112 Less: Gross book value of the transactions, net(2) (1,811,801) Net: Reclassification between operators(3) -Less: Decrease in cash from the transactions(4) (302,321) Total Adjusted Gross Assets(5) $ 20,475,846 (1) Reflects an addition to total assets to present our total share of each joint venture’s gross assets. See below for details of the calculation. While we do not control any of our unconsolidated real estate joint venture arrangements and do not have direct legal claim to the underlying assets of the unconsolidated real estate joint ventures, we believe this adjustment allows investors to view certain concentration information on a basis comparable to the remainder of our real estate portfolio. This presentation is also consistent with how our management team reviews our portfolio (dollar amounts in thousands): Real estate joint venture total gross real estate and other assets $ 5,993,609 Weighted-average equity ownership percentage 55% $ 3,304,133 Investments in unconsolidated real estate joint ventures(A) (1,572,021) Incremental gross assets of our investments in unconsolidated real estate joint ventures $ 1,732,112 (A) Includes amount shown on the “Investments in unconsolidated real estate joint ventures” line on our consolidated balance sheets, along with a CHF 60 million mortgage loan and included in the “Mortgage loans” line on our consolidated balance sheets. (2) Represents the gross book value of assets sold or written off due to the October 2022 commitment to sell three facilities leased to Prospect for approximately $457 million, the March 2023 commitment to sell 11 facilities currently leased to Healthscope, the March 2023 commitment to sell three facilities currently leased to Prime, and the February 2023 commitment to lease five facilities in Utah to CommonSpirit Health that are currently leased to Steward, partially offset by the addition of new gross assets from the committed transactions. See detail below (in thousands): Gross book value of assets in transactions $ (1,387,147) Non-cash rent write-offs related to disposals (424,654) Gross book value of the transactions $ (1,811,801) (3) Reclass of $0.9 billion reclass of gross assets between Steward and CommonSpirit Health as part of the committed transaction described in Note (2). (4) Represents cash expected from the proceeds generated by the transactions, along with cash on hand to reduce debt as detailed below (in thousands): Expected cash proceeds generated by the transactions $ 1,407,200 Reduction of revolver balance and payoff of Australia term loan (1,709,521) Net decrease in cash from the transactions $ (302,321) (5) Total adjusted gross assets is total assets before accumulated depreciation/amortization (adjusted for our investments in unconsolidated real estate joint ventures), assumes material transaction commitments are completed, and assumes cash on hand at period-end and cash generated from or to be generated from transaction commitments or financing activities subsequent to period-end are either used in these transactions or used to reduce debt. We believe total adjusted gross assets is useful to investors as it provides a more current view of our portfolio and allows for a better understanding of our concentration levels as our commitments close. MEDICAL PROPERTIES TRUST | SUPPLEMENTAL INFORMATION | Q1 2023 21

1000 Urban Center Drive, Suite 501 Birmingham, AL 35242 (205) 969-3755 NYSE: MPW www.medicalpropertiestrust.com Contact: Drew Babin, Senior Managing Director of Corporate Communications (646) 884-9809 or dbabin@medicalpropertiestrust.com or Tim Berryman, Managing Director of Investor Relations (205) 397-8589 or tberryman@medicalpropertiestrust.com