SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)


             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                                (Amendment No. )


                         Medical Properties Trust, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $0.001 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    58463J304
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                                  July 7, 2005
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

          [_] Rule 13d-1(b)

          [X] Rule 13d-1(c)

          [_] Rule 13d-1(d)

CUSIP No. 58463J304 --------------------- 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Jeffrey L. Feinberg(1) 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [X] 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5. SOLE VOTING POWER 0 6. SHARED VOTING POWER 2,399,300 7. SOLE DISPOSITIVE POWER 0 8. SHARED DISPOSITIVE POWER 2,399,300 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,399,300 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.4% 12. TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- (1) The securities reported herein are held by i) Jeffrey L. Feinberg in his personal account and ii) JLF Partners I, L.P., JLF Partners II, L.P., and JLF Offshore Fund, Ltd., to which JLF Asset Management, L.L.C. serves as the management company and/or investment manager. Jeffrey L. Feinberg is the managing member of JLF Asset Management, L.L.C.

CUSIP No. 58463J304 --------------------- 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) JLF Asset Management, L.L.C.(2) 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [X] 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5. SOLE VOTING POWER 0 6. SHARED VOTING POWER 2,399,300 7. SOLE DISPOSITIVE POWER 0 8. SHARED DISPOSITIVE POWER 2,399,300 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,399,300 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.4% 12. TYPE OF REPORTING PERSON* OO - -------------------------------------------------------------------------------- (2) The securities reported herein are held by i) Jeffrey L. Feinberg in his personal account and ii) JLF Partners I, L.P., JLF Partners II, L.P., and JLF Offshore Fund, Ltd., to which JLF Asset Management, L.L.C. serves as the management company and/or investment manager.

CUSIP No. 58463J304 --------------------- Item 1(a). Name of Issuer: Medical Properties Trust, Inc. -------------------------------------------------------------------- Item 1(b). Address of Issuer's Principal Executive Offices: 1000 Urban Center Drive Suite 501 Birmingham, Alabama 35242 -------------------------------------------------------------------- Item 2(a). Name of Person Filing: Jeffrey L. Feinberg JLF Asset Management, L.L.C. -------------------------------------------------------------------- Item 2(b). Address of Principal Business Office, or if None, Residence: Jeffrey L. Feinberg c/o JLF Asset Management, L.L.C. 2775 Via de la Valle, Suite 204 Del Mar, CA 92014 JLF Asset Management, L.L.C. 2775 Via de la Valle, Suite 204 Del Mar, CA 92014 ------------------------------------------------------------------- Item 2(c). Citizenship: Jeffrey L. Feinberg - United States JLF Asset Management, L.L.C. - United States -------------------------------------------------------------------- Item 2(d). Title of Class of Securities: Common Stock, $0.001 par value -------------------------------------------------------------------- Item 2(e). CUSIP Number: 58463J304 -------------------------------------------------------------------- Item 3. If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) of (c), Check Whether the Person Filing is a: (a) [_] Broker or dealer registered under Section 15 of the Exchange Act. (b) [_] Bank as defined in Section 3(a)(6) of the Exchange Act. (c) [_] Insurance company as defined in Section 3(a)(19) of the Exchange Act. (d) [_] Investment company registered under Section 8 of the Investment Company Act. (e) [X] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E); (f) [_] An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F); (g) [_] A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G); (h) [_] A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act; (i) [_] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act; (j) [_] Group, in accordance with Rule 13d-1(b)(1)(ii)(J). Item 4. Ownership. Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. (a) Amount beneficially owned: Jeffrey L. Feinberg: 2,399,300 shares JLF Asset Management, L.L.C.: 2,399,300 shares ---------------------------------------------------------------------- (b) Percent of class: Jeffrey L. Feinberg: 6.4% JLF Asset Management, L.L.C.: 6.4% ---------------------------------------------------------------------- (c) Number of shares as to which Jeffrey L. Feinberg has: (i) Sole power to vote or to direct the vote 0 ----------------, (ii) Shared power to vote or to direct the vote 2,399,300 ----------------, (iii) Sole power to dispose or to direct the disposition of 0 ----------------, (iv) Shared power to dispose or to direct the disposition of 2,399,300 ----------------. Number of shares as to which JLF Asset Management, L.L.C. has: (i) Sole power to vote or to direct the vote 0 ----------------, (ii) Shared power to vote or to direct the vote 2,399,300 ----------------, (iii) Sole power to dispose or to direct the disposition of 0 ----------------, (iv) Shared power to dispose or to direct the disposition of 2,399,300 ----------------. Item 5. Ownership of Five Percent or Less of a Class. If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities check the following [ ]. N/A ---------------------------------------------------------------------- Item 6. Ownership of More Than Five Percent on Behalf of Another Person. If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than five percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. N/A ---------------------------------------------------------------------- Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. If a parent holding company or Control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. N/A ---------------------------------------------------------------------- Item 8. Identification and Classification of Members of the Group. If a group has filed this schedule pursuant to ss.240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to ss.240.13d-1(c) or ss.240.13d-1(d), attach an exhibit stating the identity of each member of the group. N/A ---------------------------------------------------------------------- Item 9. Notice of Dissolution of Group. Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. N/A ---------------------------------------------------------------------- Item 10. Certifications. Certification for Rule 13d-1(c): By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. July 25, 2005 ---------------------------------------- (Date) /s/ Jeffrey L. Feinberg(3) ---------------------------------------- Jeffrey L. Feinberg JLF Asset Management, L.L.C. By: /s/ Jeffrey L. Feinberg ---------------------------------------- Managing Member (3) The Reporting Persons disclaim beneficial ownership except to the extent of their pecuniary interest therein.

Exhibit A AGREEMENT The undersigned agree that this Schedule 13G dated July 25, 2005 relating to the Common Stock, $0.001 par value, of Medical Properties Trust, Inc. shall be filed on behalf of the undersigned. /s/ Jeffrey L. Feinberg -------------------------- Jeffrey L. Feinberg JLF Asset Management, L.L.C. By: /s/ Jeffrey L. Feinberg ------------------------------ Name: Jeffrey L. Feinberg Title: Managing Member 02717.0005 #587544